J
Jürgen Roes
Researcher at University College London
Publications - 43
Citations - 9268
Jürgen Roes is an academic researcher from University College London. The author has contributed to research in topics: Gene targeting & B cell. The author has an hindex of 30, co-authored 43 publications receiving 8774 citations. Previous affiliations of Jürgen Roes include University of Cologne.
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Journal ArticleDOI
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
TL;DR: The importance of the membrane form of the μ chain in B-cell development is assessed by generating mice lacking this chain by disrupting one of the membranes exons of the gene encoding the μ-chain constant region by gene targeting in mouse embryonic stem cells.
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Killing activity of neutrophils is mediated through activation of proteases by K + flux
Emer P. Reeves,Hui Lu,Hugues Lortat Jacobs,Carlo Messina,Steve Bolsover,Giorgio Gabella,Eric O. Potma,Alice Warley,Jürgen Roes,Anthony W. Segal +9 more
TL;DR: It is shown that mice made deficient in neutrophil-granule proteases but normal in respect of superoxide production and iodinating capacity, are unable to resist staphylococcal and candidal infections.
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Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.
Harold Cremer,Rita Lange,Annette Christoph,Markus Plomann,Gaby Vopper,Jürgen Roes,Russell W. Brown,Stanley A. Baldwin,Philipp J. Kraemer,Stephen W. Scheff +9 more
TL;DR: It is shown here that N-CAM-deficient mice generated by gene targeting appear healthy and fertile, but adult mutants show a 10% reduction in overall brain weight and a 36% decline in size of the olfactory bulb.
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Differential Roles of Macrophages in Diverse Phases of Skin Repair
Tina Lucas,Ari Waisman,Rajeev Ranjan,Jürgen Roes,Thomas Krieg,Werner Müller,Axel Roers,Sabine A. Eming +7 more
TL;DR: The results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events.
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B Lymphocyte-Specific, Cre-mediated Mutagenesis in Mice
TL;DR: To selectively modify genes in B lymphocytes, mice are generated (designated CD19-Cre) which express cre under the transcriptional control of the B lineage-restricted CD19 gene.