T
Tina Lucas
Researcher at Goethe University Frankfurt
Publications - 17
Citations - 2078
Tina Lucas is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Endothelial stem cell & Bone marrow. The author has an hindex of 12, co-authored 17 publications receiving 1647 citations. Previous affiliations of Tina Lucas include University of Cologne.
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Journal ArticleDOI
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Tina Lucas,Ari Waisman,Rajeev Ranjan,Jürgen Roes,Thomas Krieg,Werner Müller,Axel Roers,Sabine A. Eming +7 more
TL;DR: The results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events.
Journal ArticleDOI
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Sebastian Willenborg,Tina Lucas,Geert van Loo,Geert van Loo,Johanna A. Knipper,Thomas Krieg,Ingo Haase,Bent Brachvogel,Matthias Hammerschmidt,Andras Nagy,Napoleone Ferrara,Manolis Pasparakis,Sabine A. Eming +12 more
TL;DR: It is shown that among the large number of inflammatory CCR2(+)Ly6C(+) macrophages that dominate the early stage of repair, only a small fraction strongly expresses VEGF-A that has nonredundant functions for the induction of vascular sprouts.
Journal ArticleDOI
Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3
Anuradha Doddaballapur,Katharina M. Michalik,Yosif Manavski,Tina Lucas,Riekelt H. Houtkooper,Xintian You,Wei Chen,Andreas M. Zeiher,Michael Potente,Stefanie Dimmeler,Reinier A. Boon +10 more
TL;DR: In this paper, the authors showed that shear stress exposure reduced glucose uptake and mitochondrial content in endothelium and showed that KLF2 overexpression recapitulates the inhibitory effects on endothelial glycolysis elicited by laminar flow.
Journal ArticleDOI
RNA Therapeutics in Cardiovascular Disease.
TL;DR: Examples of microRNAs and long noncoding RNAs, which might be promising novel targets for treatment of cardiovascular diseases, such as heart failure, acute myocardial infarction, fibrosis, as well as atherosclerosis, are summarized.
Journal ArticleDOI
Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice.
Tina Lucas,Florian Schäfer,Patricia Müller,Sabine A. Eming,Alexander Heckel,Stefanie Dimmeler +5 more
TL;DR: Light activation of caged antimiR- 92a improves healing in diabetic mice to a similar extent as conventional antimiRs and derepresses the miR-92a targets Itga5 and Sirt1, thereby regulating wound cell proliferation and angiogenesis.