R
Ralf-Jürgen Kuban
Researcher at Charité
Publications - 22
Citations - 732
Ralf-Jürgen Kuban is an academic researcher from Charité. The author has contributed to research in topics: Regulation of gene expression & Apoptosis. The author has an hindex of 13, co-authored 22 publications receiving 666 citations. Previous affiliations of Ralf-Jürgen Kuban include Humboldt State University.
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Journal ArticleDOI
STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival
Manik Chatterjee,Sarika Jain,Thorsten Stühmer,Mindaugas Andrulis,Ute Ungethüm,Ralf-Jürgen Kuban,Heike Lorentz,Kurt Bommert,Max S. Topp,Doris Krämer,Hans Konrad Müller-Hermelink,Hermann Einsele,Axel Greiner,Ralf C. Bargou +13 more
TL;DR: In situ overexpression of both Hsp90 proteins was observed in most MMs but not in monoclonal gammopathy of undetermined significance (MGUS) or in normal plasma cells, suggesting that a positive feedback loop consisting of Hsp 90alpha/beta and major signaling pathways supports the survival of MM cells.
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Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway dependent gene signatures in colorectal cancer cells.
Karsten Jürchott,Ralf-Jürgen Kuban,Till Krech,Nils Blüthgen,Ulrike Stein,Wolfgang Walther,Christian Friese,Szymon M. Kielbasa,Szymon M. Kielbasa,Ute Ungethüm,Per-Eric Lund,Thomas Knösel,Wolfgang Kemmner,Wolfgang Kemmner,Markus Morkel,Markus Morkel,Johannes Fritzmann,Peter M. Schlag,Walter Birchmeier,Tammo Krueger,Silke Sperling,Christine Sers,Hans-Dieter Royer,Hans-Dieter Royer,Hanspeter Herzel,Reinhold Schäfer +25 more
TL;DR: The MAPK-dependent gene signature in colorectal cancers is validated and provided evidence for the association of YBX1 with poor prognosis in colOREctal cancer patients, which suggests that MEK/ERK- dependent, YBx1-regulated target genes are involved in executing malignant properties.
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Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases.
TL;DR: This work identified phenylalanine 353 as primary determinant for the positional specificity of rabbit reticulocyte 15-lipoxygenase and modeling of the enzyme-substrate interaction suggested that the alignment of arachidonic acid at the active site appears to be influenced by this residue.
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A Role for E2F6 in the Restriction of Male-Germ-Cell-Specific Gene Expression
Michael Pohlers,Matthias Truss,Ute Frede,Axel Scholz,Michael Strehle,Ralf-Jürgen Kuban,Bettina Hoffmann,Markus Morkel,Carmen Birchmeier,Christian Hagemeier,Christian Hagemeier +10 more
TL;DR: It is shown that E2F6 plays an unexpected and essential role in the tissue specificity of gene expression and is essential for the long-term somatic silencing of certain male-germ-cell-specific genes, but it is dispensable for cell-cycle regulation.
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Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.
Per Lund,Weisshaupt K,Thomas Mikeska,Jammas D,Xiao-Hua Chen,Ralf-Jürgen Kuban,Ute Ungethüm,Krapfenbauer U,Hanspeter Herzel,Reinhold Schäfer,Joern Walter,Christine Sers +11 more
TL;DR: The results suggest that silencing of individual genes by DNA methylation is controlled by oncogenic signalling pathways, yet the mechanisms responsible for initial target gene suppression are variable.