R
Ralf Wassmuth
Researcher at Dresden University of Technology
Publications - 13
Citations - 548
Ralf Wassmuth is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Transplantation & Mesenchymal stem cell. The author has an hindex of 7, co-authored 13 publications receiving 521 citations.
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Journal ArticleDOI
Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders
TL;DR: Bone marrow-derived mesenchymal stromal cells (MSCs) represent a population of nonhematopoietic cells, which play a crucial role in supporting hematopoiesis and can differentiate into various cell types such as osteocytes, chondrocytes, adipocytes, and myocytes.
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Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning
Alexander H. Schmidt,Daniel M. Baier,Ute V. Solloch,A Stahr,Nezih Cereb,Ralf Wassmuth,Gerhard Ehninger,Claudia Rutt +7 more
TL;DR: The results are highly relevant for strategic planning and resource allocation of donor centers and registries for outcomes of hematopoietic stem cell transplantation.
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A multi-site study using high-resolution HLA genotyping by next generation sequencing.
Cherie Holcomb,Bryan Hoglund,Matthew W. Anderson,Lisbeth A. Blake,I. Böhme,Michael Egholm,Deborah Ferriola,Christian Gabriel,S. E. Gelber,Damian Goodridge,S. Hawbecker,R. Klein,Martha Ladner,Curt Lind,Dimitri S. Monos,Marcelo J. Pando,Johannes Pröll,David Sayer,Gudrun G. Schmitz-Agheguian,Birgitte B. Simen,B. Thiele,Elizabeth Trachtenberg,Dolly B. Tyan,Ralf Wassmuth,Shana White,Henry A. Erlich +25 more
TL;DR: It is concluded that clonal pyrosequencing using the GS FLX platform and CONEXIO ATF software allows reliable identification of HLA genotypes at high resolution.
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Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment.
Alexander H. Schmidt,Ute V. Solloch,Daniel M. Baier,A Stahr,Ralf Wassmuth,Gerhard Ehninger,Claudia Rutt +6 more
TL;DR: Analysis of genetic distances suggests the existence of three regional clusters in South (regions 6-9), East (0-1), and Northwest (2-5) Germany, which shows most favorable characteristics with respect to haplotypic and phenotypic diversity and the occurrence of rare HLA antigens.
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Genetic Variations of Interleukin-23R (1143A>G) and BPI (A645G), but Not of NOD2, Are Associated with Acute Graft-versus-Host Disease after Allogeneic Transplantation
Martin Wermke,Stefanie Maiwald,Renate Schmelz,Christian Thiede,Johannes Schetelig,Gerhard Ehninger,Martin Bornhäuser,Ralf Wassmuth +7 more
TL;DR: NOD2 SNPs did not predict aGVHD, but IL-23R(1142A>G) and BPI(A645G) SNPs appeared to be promising markers in this regard, and the importance of these markers in prediction models for GVHD and relapse remain to be defined in large prospective clinical trials.