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Birgitte B. Simen
Researcher at Hoffmann-La Roche
Publications - 48
Citations - 5004
Birgitte B. Simen is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Population & Amplicon. The author has an hindex of 28, co-authored 46 publications receiving 4707 citations. Previous affiliations of Birgitte B. Simen include Yale University & Thomas Jefferson University.
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Journal ArticleDOI
Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing
Scott D. Boyd,Eleanor L. Marshall,Jason D. Merker,Jay M. Maniar,Lyndon N. Zhang,Bita Sahaf,Carol D. Jones,Birgitte B. Simen,Bozena Hanczaruk,Khoa D. Nguyen,Kari C. Nadeau,Michael Egholm,David B. Miklos,James L. Zehnder,Andrew Fire +14 more
TL;DR: It is shown that massively parallel DNA sequencing of rearranged immune receptor loci can provide direct detection and tracking of immune diversity and expanded clonal lymphocyte populations in physiological and pathological contexts.
Journal ArticleDOI
Assuring the quality of next-generation sequencing in clinical laboratory practice
Amy S. Gargis,Lisa V. Kalman,Meredith W Berry,David P. Bick,David Dimmock,Tina Hambuch,Fei Lu,Elaine Lyon,Karl V. Voelkerding,Barbara A. Zehnbauer,Richa Agarwala,Sarah F. Bennett,Bin Chen,Ephrem L H Chin,John G. Compton,Soma Das,Daniel H. Farkas,Matthew J. Ferber,Birgit Funke,Manohar R. Furtado,Lilia Ganova-Raeva,Ute Geigenmüller,Sandra J Gunselman,Madhuri Hegde,Philip L. F. Johnson,Andrew Kasarskis,Shashikant Kulkarni,Thomas Lenk,CS Jonathan Liu,Megan Manion,Teri A. Manolio,Elaine R. Mardis,Jason D. Merker,Mangalathu S. Rajeevan,Martin G. Reese,Heidi L. Rehm,Birgitte B. Simen,Joanne M. Yeakley,Justin M. Zook,Ira M. Lubin +39 more
TL;DR: This research highlights the need to understand more fully the role of Epstein-Barr virus in infectious disease and its role in Hunter-LaSalle syndrome.
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Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.
Birgitte B. Simen,Jan Fredrik Simons,Katherine Huppler Hullsiek,Richard M. Novak,Rodger D. MacArthur,John D. Baxter,Chunli Huang,Christine Lubeski,Gregory S. Turenchalk,Michael S. Braverman,Brian Desany,Jonathan M. Rothberg,Michael Egholm,Michael J. Kozal +13 more
TL;DR: Ultra-deep sequencing identified a significantly larger proportion of HIV-infected, treatment-naive persons as harboring drug-resistant viral variants.
Journal ArticleDOI
Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements
Scott D. Boyd,Bruno A. Gaëta,Katherine J. L. Jackson,Andrew Fire,Eleanor L. Marshall,Jason D. Merker,Jay M. Maniar,Lyndon N. Zhang,Bita Sahaf,Carol D. Jones,Birgitte B. Simen,Bozena Hanczaruk,Khoa D. Nguyen,Kari C. Nadeau,Michael Egholm,David B. Miklos,James L. Zehnder,Andrew M. Collins +17 more
TL;DR: The extent of genotypic variation between individuals is highlighted by an individual with aplastic anemia who appears to lack six contiguous IGHD genes on both chromosomes, and these deletions significantly alter the potential expressed IGH repertoire, and possibly immune function, in this individual.
Journal ArticleDOI
Convergent antibody signatures in human dengue.
Poornima Parameswaran,Yi Liu,Krishna M. Roskin,Katherine K.L. Jackson,Vaishali P. Dixit,Ji-Yeun Lee,Karen L. Artiles,Simona Zompi,Maria José Vargas,Birgitte B. Simen,Bozena Hanczaruk,Kim R. McGowan,Muhammad Tariq,Nader Pourmand,Daphne Koller,Angel Balmaseda,Scott D. Boyd,Eva Harris,Andrew Fire +18 more
TL;DR: Dengue provides a striking example of a human viral infection where convergent immune signatures can be identified in multiple individuals, and could facilitate surveillance of immunological memory in communities.