R
Rama Shanker Verma
Researcher at Indian Institute of Technology Madras
Publications - 167
Citations - 3945
Rama Shanker Verma is an academic researcher from Indian Institute of Technology Madras. The author has contributed to research in topics: Stem cell & Mesenchymal stem cell. The author has an hindex of 30, co-authored 159 publications receiving 3160 citations. Previous affiliations of Rama Shanker Verma include University of Pennsylvania & Thapar University.
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ROMO1 regulates RedOx states and serves as an inducer of NF-κB-driven EMT factors in Fanconi anemia.
TL;DR: The role of ROMO1 is revealed and its link in regulating RedOx states and in the activation of NF-κB-dependent EMT factors in FA is demonstrated.
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Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells.
TL;DR: Interactions among β-C, AO-(2) and P in the induction of apoptosis on A431 and HaCaT cells suggest the combination of β-caryophyllene with aromadendrene oxide 2 and phytol could be potential therapeutics for the treatment of skin epidermoid cancer and precancerous cells.
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Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
Pavithra Shyamsunder,Milan Ešner,Maunish Barvalia,Yu Jun Wu,Tomáš Loja,Huat Bay Boon,Matilde E. Lleonart,Rama Shanker Verma,Lumir Krejci,Alex Lyakhovich +9 more
TL;DR: It is demonstrated that FA cells have increased number of autophagic (presumably mitophagic) events and accumulate dysfunctional mitochondria due to an impaired ability to degrade them, and mitochondrial fission accompanied by oxidative stress (OS) is a prerequisite condition for mitophagy in FA.
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Folate (pteroylglutamate) uptake in human red blood cells, erythroid precursors and KB cells at high extracellular folate concentrations. Evidence against a role for specific folate-binding and transport proteins.
TL;DR: Raising the EFC 500-fold higher than controls during erythropoiesis in vitro resulted in reversal of the expected anti-(placental folate-receptor)-antiserum-induced megaloblastic changes in orthochromatic normoblasts derived from burst-forming unit-erythroid colonies.
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GM-CSF-DFF40: a novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells.
TL;DR: The chimeric protein GM-CSF-DFF40 was found to mediate targeted killing of AML cells by inducing apoptosis and can act as a prospective candidate for targeted therapy of AMl and other malignancies where GM- CSF receptor expression is upregulated.