Showing papers in "Phytomedicine in 2018"

TL;DR: It is revealed that DHQ possesses kidney protection effects including attenuating urine microalbumin excretion, hyperglycemia and lipid metabolism disorders, and mitigating renal histopathological lesions on DN, and one of the possible renal-protective mechanisms is suppressing ROS and NLRP3 inflammasome.

TL;DR: Though a panel of natural products and herb extracts demonstrate protective effects on DOX-induced cardiotoxicity in cells and animal models, their therapeutic potentials for clinical needs further investigation.

TL;DR: A comprehensive review ofSSs provides novel insights and perspectives on the limitations of current studies and the importance of metabolism study and the dose-pharmacological/toxic relationship of SSs for the future discovery of SSS-based therapeutic strategies and clinical safe practice.

TL;DR: It is demonstrated that chinmedomics is novel strategy for discovering the potential effective constituents from herbal formula, which are recognized as Q-markers for Shengmai San.

TL;DR: It is proposed that genistein exerts anticancer activity in pancreatic cancer cells through induction of ROS mediated mitochondrial apoptosis, cell cycle arrest and regulation of STAT3 and may therefore prove beneficial in the management of pancreatic cancers cancer.

TL;DR: The therapeutic effects of natural products on CKD are reviewed and the molecular mechanisms of their anti-fibrosis revealed, providing comprehensive insights into pathophysiological mechanisms of CKD and natural products against renal fibrosis are provided.

TL;DR: 25-O-methylalisol F (MAF) simultaneously targeted multiple RAS components and it was a novel RAS inhibitor, which has an important effect on crosstalk between the TGF-β/Smad and Wnt/β-catenin pathway in EMT process by activation of RAS.

TL;DR: A comprehensive review regarding the phytochemistry, pharmacokinetic features and toxicity of Fuzi suggests that the co-administration of Fizi with drugs that are substrates of DMEs and/or ETs may cause herb-drug interactions (HDIs).

TL;DR: The transitivity and traceability system has been established based on quality markers, especially on how to control the production process under Good Engineering Practices, as well as to implement the risk management for quality and process control in herbal medicine production.

TL;DR: The studied oleanane-type triterpene saponin is a good cytotoxic molecule that deserve more detailed exploration in the future, to develop novel cytot toxic drugs to combat both sensitive and drug-resistant cancers.

TL;DR: Melatonin is an adaptation hormone playing an important role in regulation of homeostasis in organisms under stress, and for the first time is reported that the molecular mechanism of actions of melatonin and plant adaptogens are alike.

TL;DR: In vitro and in vivo studies suggests that pentacyclic triterpenes effectively downregulate various factors related to metabolic syndrome and may serve as promising candidates for clinical trials for the management of metabolic syndrome.

TL;DR: Although the mechanisms of pain mitigating effects are not very clear, there is compelling evidence proved that curcumin plays an essential role, however, further high-quality clinical studies should be undertaken to establish the clinical effectiveness ofCurcumin in patients suffering from pathological pain.

TL;DR: The effectiveness of using quercetin, at least in part, via inhibiting FZD7 to combat chemoresistance is suggested and quercETin could be developed into an efficient natural sensitizer for resistant human hepatocellular carcinoma.

TL;DR: Berberine improves lipid profiles in dyslipidaemias with satisfactory safety and should be interpreted with caution because of the high clinical heterogeneity and high risk of bias in the included trials.

TL;DR: The results showed that the ginseng samples from 2- to 6-year-old could be well separated in the orthogonal projections on the latent structure - discrimination analysis (OPLS-DA) using the markers screened by the established statistical procedure, which could reduce approximately 20% of the insignificant markers and false positive discoveries.

TL;DR: This study demonstrates that ligustilde attenuates vascular inflammation and activate defense system of endothelial cell in HUVECs, a bioactive compound which might prevent cardiovascular complications such as thrombosis or atherosclerosis.

TL;DR: Pretreatment with SP led to decreased levels of ALT and AST in APAP mice, without affecting APAP metabolism, and the protective effects of SP are associated with the activation of the Nrf-2/HO-1-SOD-2 signaling pathway.

TL;DR: The use of Q-biomarkers in vivo related to specific diseases as a new strategy for the quality evaluation of Chinese herbal medicine would provide a new perspective to standardise and globalise TCM.

TL;DR: Naturally occurring flavonoids discussed in the present article have optimal immunomodulation to prevent immune-mediated disorders through management of Th1/Th2 cytokine balance.

TL;DR: Rosmarinic acid was able to prevent and also attenuate CCI-induced behavioral features in prophylactic as well as treatment groups, respectively, which further support the use of rosemary in traditional medicine to alleviate pain.

TL;DR: Results indicate that icariin is likely to be a candidate for bone-related disease treatment and that icARIin provides insights into the molecular mechanisms that influence RANKL-induced osteoclast differentiation.

TL;DR: In this article, the authors investigated the preventive effect of salvianolate on the pathogenesis of AF in post-myocardial infarction (MI) rats and to elucidate the potential mechanisms.

TL;DR: Harvest timing had a significant impact on the amounts of bioactive flavonoids and the anti-lipase activities of CRP extracts, and polymethoxyflavones played a significant role in the hypolipidemic effect ofCRP.

TL;DR: The core concept of Q-marker has helped to break through the bottleneck of the current fragmented quality research of TCM and improved the scientificity, integrity and systematicness of quality control.

TL;DR: Ginkgo biloba extract EGb 761 displayed anti-neuroinflammatory activity in LPS-activated primary microglia cells and was able to reduce neuroinflammatory activation by targeting the COX/PGE2 pathway.

TL;DR: The three halophytes studies could be considered as potential sources of biologically-active compounds for novel phytopharmaceuticals development.

TL;DR: EO-biopolymer dressings or scaffolds have become promising artifacts regarding wound treatments, especially in chronic wounds, where treating infection and inflammation are still important issues.

TL;DR: Evaluated compounds of Hypericum afrum and Cytisus villosus have properties indicative of potential neuroprotective ability and may be new candidates for selective MAO-A and B inhibitors and the most important residues involved in the selective recognition of molecules in the MAOs enzymatic clefts are identified.

TL;DR: Saffron possesses potent anti-tumor properties and represents an efficacious and safe treatment, and appears to be via various mechanisms of saffron-induced anticancer effects.