R
Rana Dajani
Researcher at University of Dundee
Publications - 17
Citations - 2365
Rana Dajani is an academic researcher from University of Dundee. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 9 publications receiving 2235 citations. Previous affiliations of Rana Dajani include Institute of Cancer Research.
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Journal ArticleDOI
GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
Laurent Meijer,Alexios-Leandros Skaltsounis,Prokopios Magiatis,Panagiotis Polychronopoulos,Marie Knockaert,Maryse Leost,Xiaozhou P. Ryan,Claudia Alin Vonica,Ali H. Brivanlou,Rana Dajani,Claudia Crovace,Cataldo Tarricone,Andrea Musacchio,S. Mark Roe,Laurence H. Pearl,Paul Greengard +15 more
TL;DR: 6-bromoindirubins provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3, and closely mimicked Wnt signaling in Xenopus embryos.
Journal ArticleDOI
Crystal Structure of Glycogen Synthase Kinase 3β: Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition
Rana Dajani,Elizabeth Fraser,S. Mark Roe,Neville Young,Valerie M. Good,Trevor Clive Dale,Laurence H. Pearl +6 more
TL;DR: The location of this oxyanion binding site in the substrate binding cleft indicates direct coupling of P+4 phosphate-primed substrate binding and catalytic activation, explains the ability of GSK3 beta to processively hyperphosphorylate substrates with Ser/Thr pentad-repeats, and suggests a mechanism for autoinhibition.
Journal ArticleDOI
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex
Rana Dajani,Elizabeth Fraser,S. Mark Roe,Margaret Yeo,Valerie M. Good,Vivienne Thompson,Trevor Clive Dale,Laurence H. Pearl +7 more
TL;DR: The structure confirms the co‐localization of the binding sites for axin and FRAT in the C‐terminal domain of GSK3β, but reveals significant differences in the interactions made by axinand FRAT, mediated by conformational plasticity of the 285—299 loop in GSK2β.
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X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3 MOLECULAR MODELING AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS DEMONSTRATE A MOLECULAR BASIS FOR SULFOTRANSFERASE SUBSTRATE SPECIFICITY
Rana Dajani,Anne Cleasby,Margarete Neu,Alan J. Wonacott,Harren Jhoti,Alan M. Hood,Sandeep Modi,Anne Hersey,Jyrki Taskinen,Robert M. Cooke,Gary R. Manchee,Michael W.H. Coughtrie +11 more
TL;DR: QSAR analysis revealed that the SULT1A3 enzyme is highly selective for catechols, and catecholamines in particular, and that hydrogen bonding groups and lipophilicity (cLogD) strongly influenced K m .
Journal ArticleDOI
Identification of the Axin and Frat Binding Region of Glycogen Synthase Kinase-3
Elizabeth Fraser,Neville Young,Rana Dajani,Jonathan Franca-Koh,Jonathan Ryves,Robin S.B. Williams,Margaret Yeo,Marie-Therese Webster,Christopher A. Richardson,Matthew J. Smalley,Laurence H. Pearl,Adrian J. Harwood,Trevor Clive Dale +12 more
TL;DR: It is shown that GSK-3 forms a low affinity homodimer that is disrupted by binding to Axin and Frat, arguing that Axin interactions alone cannot explain the regulation of T-cell factor-mediated gene expression.