GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
Laurent Meijer,Alexios-Leandros Skaltsounis,Prokopios Magiatis,Panagiotis Polychronopoulos,Marie Knockaert,Maryse Leost,Xiaozhou P. Ryan,Claudia Alin Vonica,Ali H. Brivanlou,Rana Dajani,Claudia Crovace,Cataldo Tarricone,Andrea Musacchio,S. Mark Roe,Laurence H. Pearl,Paul Greengard +15 more
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TLDR
6-bromoindirubins provide a new scaffold for the development of selective and potent pharmacological inhibitors of GSK-3, and closely mimicked Wnt signaling in Xenopus embryos.About:
This article is published in Chemistry & Biology.The article was published on 2003-12-01 and is currently open access. It has received 799 citations till now. The article focuses on the topics: Indirubin.read more
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The Wnt signaling pathway in development and disease.
Catriona Y. Logan,Roel Nusse +1 more
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Noboru Sato,Laurent Meijer,Laurent Meijer,Leandros Skaltsounis,Paul Greengard,Ali H. Brivanlou +5 more
TL;DR: It is shown that activation of the canonical Wnt pathway is sufficient to maintain self-renewal of both HESCs and MESCs, and the use of GSK-3-specific inhibitors such as BIO may have practical applications in regenerative medicine.
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Impact of natural products on developing new anti-cancer agents
TL;DR: This work presents a meta-analysis of the “Metagenome” of Cyanophytes and Marine Microbes, which highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals.
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Toll-like receptor—mediated cytokine production is differentially regulated by glycogen synthase kinase 3
TL;DR: It is reported that glycogen synthase kinase 3 differentially regulates TLR-mediated production of pro- and anti-inflammatory cytokines in mice receiving lipopolysaccharide and mediated protection from endotoxin shock.
References
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
TL;DR: The LIGPLOT program automatically generates schematic 2-D representations of protein-ligand complexes from standard Protein Data Bank file input giving a simple and informative representation of the intermolecular interactions and their strengths, including hydrogen bonds, hydrophobic interactions and atom accessibilities.
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Specificity and mechanism of action of some commonly used protein kinase inhibitors
TL;DR: The results demonstrate that the specificities of protein kinase inhibitors cannot be assessed simply by studying their effect on kinases that are closely related in primary structure, and proposes guidelines for the use of protein Kinase inhibitors in cell-based assays.
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GSK-3: tricks of the trade for a multi-tasking kinase.
TL;DR: Since increased GSK-3 activity may be linked to pathology in diseases such as Alzheimer's disease and non-insulin-dependent diabetes mellitus, several new G SKS-3 inhibitors, such as the aloisines, the paullones and the maleimides, have been developed and hold promise as therapeutic agents.