R
Randolph V. Norheim
Researcher at Pacific Northwest National Laboratory
Publications - 31
Citations - 1296
Randolph V. Norheim is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Ion & Ion-mobility spectrometry. The author has an hindex of 18, co-authored 28 publications receiving 973 citations. Previous affiliations of Randolph V. Norheim include Environmental Molecular Sciences Laboratory.
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Journal ArticleDOI
Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations
Liulin Deng,Ian K. Webb,Sandilya V. B. Garimella,Ahmed M. Hamid,Xueyun Zheng,Randolph V. Norheim,Spencer A. Prost,Gordon A. Anderson,Jeremy A. Sandoval,Erin S. Baker,Yehia M. Ibrahim,Richard D. Smith +11 more
TL;DR: The new SLIM SUPER high resolution TWIM platform has broad utility in conjunction with MS and is expected to enable a broad range of previously challenging or intractable separations.
Journal ArticleDOI
Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module.
Liulin Deng,Yehia M. Ibrahim,Ahmed M. Hamid,Sandilya V. B. Garimella,Ian K. Webb,Xueyun Zheng,Spencer A. Prost,Jeremy A. Sandoval,Randolph V. Norheim,Gordon A. Anderson,Aleksey V. Tolmachev,Erin S. Baker,Richard D. Smith +12 more
TL;DR: The development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry and it provides a foundation for the development of much higher resolution SLIM devices based upon both considerably longer path lengths and multipass designs.
Journal ArticleDOI
Experimental Evaluation and Optimization of Structures for Lossless Ion Manipulations for Ion Mobility Spectrometry with Time-of-Flight Mass Spectrometry
Ian K. Webb,Sandilya V. B. Garimella,Aleksey V. Tolmachev,Tsung-Chi Chen,Xinyu Zhang,Randolph V. Norheim,Spencer A. Prost,Brian L. LaMarche,Gordon A. Anderson,Yehia M. Ibrahim,Richard D. Smith +10 more
TL;DR: Both geometries provide IMS resolving powers at the theoretical limit (R ∼ 58) showing that degraded resolution from a “racetrack” effect from turning around a corner can be successfully avoided, and the capability also was maintained for essentially lossless ion transmission.
Journal ArticleDOI
Development of a new ion mobility time-of-flight mass spectrometer
Yehia M. Ibrahim,Erin S. Baker,William F. Danielson,Randolph V. Norheim,David C. Prior,Gordon A. Anderson,Mikhail E. Belov,Richard D. Smith +7 more
TL;DR: In this article, a new ion mobility spectrometer (IMS) platform was developed to improve upon the sensitivity and reproducibility of previous platforms, and further enhance IMS-MS utility for broad 'panomics' measurements.
Journal ArticleDOI
Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry.
Liulin Deng,Yehia M. Ibrahim,Erin S. Baker,Noor A. Aly,Ahmed M. Hamid,Xing Zhang,Xueyun Zheng,Sandilya V. B. Garimella,Ian K. Webb,Spencer A. Prost,Jeremy A. Sandoval,Randolph V. Norheim,Gordon A. Anderson,Aleksey V. Tolmachev,Richard D. Smith +14 more
TL;DR: A new approach using Structures for Lossless Ion Manipulations (SLIM) to enable long serpentine path ion mobility spectrometry (IMS) separations followed by MS analyses, which provides previously unachieved resolution for biomolecular species, in conjunction with more effective ion utilization.