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Xueyun Zheng
Researcher at Pacific Northwest National Laboratory
Publications - 55
Citations - 2509
Xueyun Zheng is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Ion-mobility spectrometry & Mass spectrometry. The author has an hindex of 26, co-authored 46 publications receiving 1799 citations. Previous affiliations of Xueyun Zheng include Xiamen University & University of California, Berkeley.
Papers
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Journal ArticleDOI
An Interlaboratory Evaluation of Drift Tube Ion Mobility-Mass Spectrometry Collision Cross Section Measurements.
Sarah M. Stow,Tim J. Causon,Xueyun Zheng,Ruwan T. Kurulugama,Teresa Mairinger,Jody C. May,Emma E. Rennie,Erin S. Baker,Richard D. Smith,John A. McLean,Stephan Hann,John C. Fjeldsted +11 more
TL;DR: Improvements on the measurement accuracy of experimental parameters influencing IM separations provide standardized drift tube, nitrogen CCS values (DTCCSN2) for over 120 unique ion species with the lowest measurement uncertainty to date.
Journal ArticleDOI
A Conserved PLPLRT/SD Motif of STING Mediates the Recruitment and Activation of TBK1
Baoyu Zhao,Fenglei Du,Pengbiao Xu,Chang Shu,Banumathi Sankaran,Samantha L. Bell,Mengmeng Liu,Yuanjiu Lei,Xinsheng Gao,Xiaofeng Fu,Fanxiu Zhu,Yang Liu,Arthur Laganowsky,Xueyun Zheng,Jun-Yuan Ji,A. Philip West,Robert O. Watson,Pingwei Li +17 more
TL;DR: A molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 binding.
Journal ArticleDOI
Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease
SangHyun Lee,Xueyun Zheng,Janarthanan Krishnamoorthy,Masha G. Savelieff,Hyun Min Park,Hyun Min Park,Jeffrey R. Brender,Jin Hoon Kim,Jin Hoon Kim,Jeffrey S. Derrick,Akiko Kochi,Hyuck Jin Lee,Cheal Kim,Ayyalusamy Ramamoorthy,Michael T. Bowers,Mi Hee Lim,Mi Hee Lim +16 more
TL;DR: It is demonstrated that a rational structure-based design strategy can generate a small molecule that can target and modulate multiple factors, providing a new tool to uncover and address AD complexity.
Journal ArticleDOI
Serpentine Ultralong Path with Extended Routing (SUPER) High Resolution Traveling Wave Ion Mobility-MS using Structures for Lossless Ion Manipulations
Liulin Deng,Ian K. Webb,Sandilya V. B. Garimella,Ahmed M. Hamid,Xueyun Zheng,Randolph V. Norheim,Spencer A. Prost,Gordon A. Anderson,Jeremy A. Sandoval,Erin S. Baker,Yehia M. Ibrahim,Richard D. Smith +11 more
TL;DR: The new SLIM SUPER high resolution TWIM platform has broad utility in conjunction with MS and is expected to enable a broad range of previously challenging or intractable separations.
Journal ArticleDOI
A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry.
Xueyun Zheng,Noor A. Aly,Yuxuan Zhou,Kevin T. Dupuis,Aivett Bilbao,Vanessa L. Paurus,Daniel J. Orton,Ryan Wilson,Samuel H. Payne,Richard D. Smith,Erin S. Baker +10 more
TL;DR: The DTIMS collision cross section database for metabolites and xenobiotics shows clear trends in both the number of xenobiotic molecules and the proportions of these molecules in the blood stream are increasing.