R
Rangaramanujam M. Kannan
Researcher at Johns Hopkins University School of Medicine
Publications - 165
Citations - 8967
Rangaramanujam M. Kannan is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Dendrimer & Drug delivery. The author has an hindex of 48, co-authored 151 publications receiving 7614 citations. Previous affiliations of Rangaramanujam M. Kannan include Johns Hopkins University & Kennedy Krieger Institute.
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Journal ArticleDOI
Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications
TL;DR: This review focuses on several crucial issues related to the role of dendrimers as nanoscaffolding and nanocontainers, crucial principles that might be invoked for improvingdendrimer cytotoxicity properties, understanding dendricer cellular transport mechanisms and the exciting role ofDendriming as high-contrast MRI imaging agents.
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Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers
TL;DR: The in vitro release of ib uprofen from drug-dendrimer complex is appreciably slower compared to pure ibuprofen, suggesting that dendrimers may be able to carry the complexed drug inside cells efficiently.
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Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications.
TL;DR: A new ‘nanoperiodic’ concept is introduced which proposes nanoparticle structure control and the engineering of ‘critical nanoscale design parameters’ (CNDPs) as a strategy for optimizing pharmocokinetics, pharmocodynamics and site‐specific targeting of disease.
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The effect of surface functionality on cellular trafficking of dendrimers.
TL;DR: It is shown that even though all the dendrimers are taken up by fluid-phase endocytosis, significant differences in uptake mechanisms exist, which open up new possibilities of targeting therapeutic agents to specific cell organelles based on surface charge.
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Dendrimer-Based Postnatal Therapy for Neuroinflammation and Cerebral Palsy in a Rabbit Model
Sujatha Kannan,Hui Dai,Hui Dai,Raghavendra S. Navath,Raghavendra S. Navath,Bindu Balakrishnan,Bindu Balakrishnan,Amar Jyoti,Amar Jyoti,James Janisse,Roberto Romero,Rangaramanujam M. Kannan,Rangaramanujam M. Kannan +12 more
TL;DR: It is demonstrated that dendrimer-based N-acetyl-l-cysteine (NAC) therapy for brain injury suppresses neuroinflammation and leads to a marked improvement in motor function in the CP kits, and shows promise for postnatal treatment of babies suspected of having CP.