Showing papers in "International Journal of Pharmaceutics in 2003"

TL;DR: The encapsulation efficiency was highly decreased by increase of initial BSA and chitosan concentration; higher loading capacity of BSA speeded the BSA release from the nanoparticles.

TL;DR: A marked decrease in the cytot toxicity of cationic PAMAM dendrimers was noted when the surface was modified, with the addition of six lauroyl or four PEG chains being particularly effective in decreasing cytotoxicity.

TL;DR: A pump-controlled preparation method was established which enabled particle preparation under defined conditions and the reproducibility of the particle size and particle size distribution under the proposed preparation conditions was demonstrated.

TL;DR: The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies.

TL;DR: The spectrum of potential applications of bioadhesive microspheres in controlled drug delivery ranging from the small molecules, to peptides, and to the macromolecular drugs such as proteins, oligonucleotides and even DNA is presented.

TL;DR: PEGylation has been found to be suitable for modification of PAMAM dendrimers for reduction of drug leakage and hemolytic toxicity and could improve drug-loading capacity and stabilize such systems in body.

TL;DR: The in vitro release of ib uprofen from drug-dendrimer complex is appreciably slower compared to pure ibuprofen, suggesting that dendrimers may be able to carry the complexed drug inside cells efficiently.

TL;DR: The modification of chitosan with 2-iminothiolane leads, therefore to thiolated polymers, which represent a promising tool for the development of in situ gelling and/or mucoadhesive drug delivery systems.

TL;DR: Particle size of the solid lipid nanoparticles (SLN) was affected by using different emulsifiers and different lipid loads and an increase of the mean diameter from 205 to 695 nm and from 320 to 368nm was observed for the SLN prepared using benzyl alcohol and butyl lactate.

TL;DR: The in vivo oral absorption study in dogs showed that bioavailability of tacrolimus from SDF with HPMC was remarkably improved compared with the crystalline powder, and the new method makes it possible to prepare SDF of tacroliumus without dichloromethane.

TL;DR: It was concluded that 6-coumarin and osmium tetroxide could serve as useful fluorescence and electron microscopy probes, respectively, for incorporation into nanoparticles to study their cellular and tissue distribution.

TL;DR: It is suggested that microemulsions are potential vehicles for improved topical delivery of estradiol through microemulsion formulations as well as transdermal administration to improve its bioavailability, prolong activity and to optimize metabolic profile.

TL;DR: The dependence of the occlusive effect on the particle size of SLN due to film formation is presented by in vitro data and an in vivo study showed that addition of 4% SLN to a conventional o/w cream lead to an increase of skin hydration of 31% after 4 weeks.

TL;DR: It is demonstrated in the studies that these surface modified calcium phosphate nanoparticles can be used in vivo to target genes specifically to the liver.

TL;DR: Mucoadhesive patches containing 10mg miconazole nitrate exhibited sustained release over more than 5h and the addition of polyvinyl pyrrolidone (PVP) generally enhanced the release rate, while enhanced release rates were observed due to marked changes in the crystal habit of the drug.

TL;DR: Stability studies demonstrated that the itraconazole/HPMC 40/60 w/w milled melt extrudate formulation is chemically and physically stable for periods in excess of 6 months as indicated by the absence of degradation products or re-crystallization of the drug.

TL;DR: The in vitro uptake and release behaviour of cromolyn sodium, ketotifen fumarate, ketorolac tromethamine and dexamethasone sodium phosphate with silicon-containing and p-HEMA-containing hydrogel contact lenses indicated that both drug and material affected the uptake andrelease behaviour.

TL;DR: This study illustrates that cubosomes should be classified as a burst release delivery system where drug is released by diffusion from the cubic phase matrix, and that pressure ultrafiltration may have benefits over dialysis methods for measurement of drug release from colloidal particle-based drug delivery systems.

TL;DR: The dissolution rate of the poorly water-soluble drug ECU-01 is significantly enhanced due to the large surface, which is hydrophilized by adsorbed stabilizers as shown by the decreased contact angle and the decrease in contact angle.

TL;DR: Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared and 10 experiments were performed to characterize them to find out which tests should be carried out to assess efficiently the stability and the properties of an emulsified preparation.

TL;DR: The physicochemical properties, the colloidal stability in vitro and the biodistribution properties in mice of different PLGA-mPEG nanoparticle compositions were investigated and Optimum mPEG/PLGA ratios appeared to exist leading to long blood circulation times of the PLGA's nanoparticles.

TL;DR: To determine the largest size of liposomes that can retain stealth behavior conferred by poly(ethylene glycol)-DSPE, neutral liposome were studied in rabbits for their circulation and distribution and the optimum size of PEG-liposomes for prolonged circulation is 160-220 nm.

TL;DR: High-intensity ultrasonication induced considerable damage on the chitosan nanoparticles which could affect their function as drug carriers.

TL;DR: Differences in dissolution rates among crystal forms of piroxicam were attributed to differences in their wettable, where highest wettability was obtained for monohydrate and the lowest for form III.

TL;DR: The evaluation of the thermal and rheological properties of Precirol and Compritol mixtures have shown that the use of such mixtures, presenting well distinct melting properties, could be a very interesting tool for the preparation of high fatty binder content prolonged-release pellets in high shear mixers if the product temperature is carefully controlled during the pelletisation process.

TL;DR: It was found that both HPMC viscosity, the presence of Carbopol and their interaction had significant impact on the release and floating properties of the delivery system.

TL;DR: Low purity lipid possessed more negative charge and formed thicker adsorptive layer by stronger electrostatic attraction with chitosan, indicating a thicker coating layer in the resistance to flocculation.

TL;DR: This study shows that PCL-DEX copolymers successfully stabilized ethyl acetate- in-water emulsions, even in the absence of additional surfactants, whereas they were not efficient in stabilizing methylene chloride-in-waterEmulsion stabilizing abilities, which coalesced fast and irreversibly.

TL;DR: Amphotherin B was formulated in a nanosuspension as a new oral drug delivery system for the treatment of experimental visceral leishmaniasis and reduced liver parasite load by 28.6% compared to untreated controls.