Showing papers in "Drug Discovery Today in 2010"

TL;DR: This review reports on the unexpected and considerable number of peptides that are currently available as drugs and the chemical strategies that were used to bring them into the market.

TL;DR: This review focuses on several crucial issues related to the role of dendrimers as nanoscaffolding and nanocontainers, crucial principles that might be invoked for improvingdendrimer cytotoxicity properties, understanding dendricer cellular transport mechanisms and the exciting role ofDendriming as high-contrast MRI imaging agents.

TL;DR: The challenges of pharmacophore modeling and applications in drug discovery are discussed and recent advances and latest developments are described, which provide useful clues to the further development and application of pharmacophile approaches.

TL;DR: A review of the approaches of cancer nanotechnology in the advancement of cancer therapy focuses on the target-specific drug therapy and methods for early diagnosis of pathologies.

TL;DR: This review focuses on the chemical and biological properties of SLs that lead to enhanced anticancer and anti-inflammatory effects.

TL;DR: An overview of recent advances and current status of reversed cubic and hexagonal mesophases, especially with respect to their preparation methods and applications in the field of drug delivery is given.

TL;DR: This article presents an exhaustive account of various literature reports on diverse types of self-emulsifying formulations with emphasis on their formulation, characterization and in vitro analysis, with examples of currently marketed preparations.

TL;DR: After functionalization, carbon nanotubes display potentials for a variety of medicinal applications, including the diagnosis and treatment of cancer, infectious diseases and central nervous system disorders, and applications in tissue engineering.

TL;DR: This work systematically summarized the protein targets in PubChem by function, 3D structure and biological pathway, and analyzed the potency, selectivity and promiscuity of the bioactive compounds identified for these biological targets, including the chemical probes generated by the NIH Molecular Libraries Program.

TL;DR: Protein-ligand complexes are analyzed and methods that assist binding site identification, prediction of druggability and binding site comparison are discussed that have far-reaching implications in the field of drug discovery, such as the design of pocket-specific compound libraries and scoring functions.

TL;DR: The second-generation proteasome inhibitors are reviewed and the potential pharmacologic impact of their different chemical properties are assessed to result in different efficacy and safety profiles.

TL;DR: The US Tox21 collaborative program represents a paradigm shift in toxicity testing of chemical compounds from traditional in vivo tests to less expensive and higher throughput in vitro methods to prioritize compounds for further study, identify mechanisms of action and ultimately develop predictive models for adverse health effects in humans.

TL;DR: This review provides an overview of key derivatives of resveratrol as cancer therapeutics and suggests that some might provide promising tools as cancer chemopreventive agents, as well ascancer therapeutics in the prevention and treatment of cancer.

TL;DR: In this article, the authors provide an overview of mainly prospective epidemiological studies that have investigated the associations between different forms of emotional stress and the development of type 2 diabetes mellitus.

TL;DR: Some of the applications of metabolomics in cell culture analysis and some of the issues that need to be addressed to make this approach more relevant are outlined.

TL;DR: The 'Solubility Forecast Index' (SFI=clogD(pH7.4)+#Ar) is proposed as a simple, yet effective, guide to predicting solubility and highlighted statistically significant shortcomings in the applicability of octanol/water as a model system for hydrophobicity determination with poorly soluble compounds.

TL;DR: Recent progress in parasite genomics and the identification of a few biomolecular targets hold great promise for the discovery of new 'mechanism-based' antiparasitic metallodrugs.

TL;DR: A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems and of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs.

TL;DR: The emergence of a growing number of experimentally validated inhibitors of PPIs (i-PPIs) allows drug designers to use chemoinformatics and machine learning technologies to unravel the nature of the chemical space covered by the reported compounds and highlight the importance of specific shapes and/or aromatic bonds.

TL;DR: The issues associated with modeling carbohydrates are summarized and analyzed, with a detailed discussion of four of the most recently developed carbohydrate force fields, reviewed in terms of applicability to natural glycans, carbohydrate-protein complexes and the emerging area of glycomimetic drugs.

TL;DR: Major advances both in the characterization of anandamide's and 2-arachidonoylglycerol's biosynthesis and inactivation pathways and in the discovery of pharmacological tools used to interfere with their metabolism have been made and are discussed in this review.

TL;DR: Novel ligands that conform to the prevalent pharmacophore and exhibit drug-like pharmacokinetic properties have been identified and several small molecules are currently in Phase II/III clinical trials for depression, anxiety and irritable bowel syndrome.

TL;DR: Progress in the development of selective agonists and antagonists for P2Y receptors and study of knockout mice have led to new drug concepts based on these receptors, resulting in drug candidates for cystic fibrosis, dry eye disease and thrombosis.

TL;DR: The ability to qualitatively distinguish G-protein coupling has groundbreaking potential for assessing functional selectivity, a concept that is changing the way GPCR pharmacology is defined and screening strategies are designed.

TL;DR: This review provides a current understanding of the role of ROCK pathway in the regulation of vascular function and the use of ROCK inhibitors in the treatment of cardiovascular disorders.

TL;DR: The time is ripe to move from single markers for correlates of protection to a biosignature comprising a well-defined set of robust indicators in TB that can accelerate rapid screening and early selection of potential drug and vaccine candidates.

TL;DR: Common industry practices for tackling optimization challenges are summarized and how the assessment of binding thermodynamics could support medicinal chemistry efforts are reviewed to suggest that enthalpy-driven optimizations are preferred because they provide better quality compounds.

TL;DR: Toxic effects of cyclotides, whose native function is as insecticidal agents, can be removed by simple mutagenesis, thus rationalizing the apparent conundrum of proposing insecticidal Agents as leads for human therapeutics.

TL;DR: This review focuses on recent developments in computational toxicology, and the current trend is to make simpler predictions, closer to the mechanism of action, and to follow them up with in vitro or in vivo assays as appropriate.

TL;DR: Syk is an intriguing protein tyrosine kinase involved in signal transduction in a variety of cell types, and its aberrant regulation is associated with different allergic disorders and antibody-mediated autoimmune diseases such as rheumatoid arthritis, asthma and allergic rhinitis.