R
Raphael Guillot
Researcher at Grenoble Institute of Technology
Publications - 16
Citations - 821
Raphael Guillot is an academic researcher from Grenoble Institute of Technology. The author has contributed to research in topics: Bone regeneration & Surface coating. The author has an hindex of 12, co-authored 14 publications receiving 698 citations. Previous affiliations of Raphael Guillot include Centre national de la recherche scientifique.
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Journal ArticleDOI
The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating
Thomas Crouzier,Frédéric Sailhan,Frédéric Sailhan,Pierre Becquart,Raphael Guillot,Delphine Logeart-Avramoglou,Catherine Picart +6 more
TL;DR: In vivo, both uncoated and PEM-coated TCP/HAP granules loaded with rhBMP-2 exhibited both osteoconductive and osteoinductive properties, which opens perspective for coating these bioactive PEM on other types of implantable materials, including metal alloy that do not exhibit any affinity for rhB MP-2.
Journal ArticleDOI
Surface delivery of tunable doses of BMP-2 from an adaptable polymeric scaffold induces volumetric bone regeneration
M. Bouyer,Raphael Guillot,Jonathan Lavaud,Cedric Plettinx,Cécile Olivier,Véronique Curry,Jean Boutonnat,Jean-Luc Coll,Françoise Peyrin,Véronique Josserand,Georges Bettega,Catherine Picart +11 more
TL;DR: This work presents a novel means for repairing a critical size volumetric bone femoral defect in the rat by combining a osteoinductive surface coating (2D) to a polymeric scaffold (3D hollow tube) made of commercially-available PLGA.
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The stability of BMP loaded polyelectrolyte multilayer coatings on titanium
Raphael Guillot,Flora Gilde,Pierre Becquart,Frédéric Sailhan,Aurélien Lapeyrere,Delphine Logeart-Avramoglou,Catherine Picart +6 more
TL;DR: In vivo studies showed that the osteoinductive potential of BMP-2 contained in PEM-coated Ti implants was fully preserved after air-drying of the implants and sterilization at 25 kGy, and film drying or irradiation did not affect the amount of new bone tissue formation.
Journal ArticleDOI
Assessment of a polyelectrolyte multilayer film coating loaded with BMP-2 on titanium and PEEK implants in the rabbit femoral condyle.
Raphael Guillot,Isabelle Pignot-Paintrand,Jonathan Lavaud,A. Decambron,E. Bourgeois,Véronique Josserand,Delphine Logeart-Avramoglou,Eric Viguier,Catherine Picart,Catherine Picart +9 more
TL;DR: It is shown that a too high dose of BMP-2 delivered from the screw surface has a negative short-term effect on bone regeneration in close vicinity of the screws surface and the need for future dose-dependence studies on bone formation in response to osteoinductive coatings.
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Spatial patterning of BMP-2 and BMP-7 on biopolymeric films and the guidance of muscle cell fate.
Jorge Almodovar,Raphael Guillot,Claire Monge,Julien Vollaire,Šeila Selimović,Jean-Luc Coll,Ali Khademhosseini,Catherine Picart,Catherine Picart +8 more
TL;DR: Layer-by-layer films composed of poly(L-lysine) and hyaluronan were combined in a simple microfluidic device enabling spatially controlled growth factor diffusion along the film enabling an additive or synergistic effect of the two BMPs.