R
Raquel Almeida
Researcher at University of Porto
Publications - 87
Citations - 3505
Raquel Almeida is an academic researcher from University of Porto. The author has contributed to research in topics: Intestinal metaplasia & CDX2. The author has an hindex of 28, co-authored 84 publications receiving 2959 citations. Previous affiliations of Raquel Almeida include Institute of Molecular Pathology and Immunology of the University of Porto.
Papers
More filters
Journal ArticleDOI
RNA-Binding Proteins in Cancer: Old Players and New Actors
TL;DR: Evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer are reviewed.
Journal ArticleDOI
Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
TL;DR: Emerging evidence indicates that formation of many glycosidic linkages is covered by large homologous glycosyltransferase gene families, and that the existence of multiple enzyme isoforms provides a degree of redundancy as well as a higher level of regulation of the glycoforms synthesized.
Journal ArticleDOI
Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas.
Raquel Almeida,Elisabete Silva,Filipe Santos-Silva,Debra G. Silberg,Jiangfu Wang,Carmen De Bolós,Leonor David +6 more
TL;DR: Assessment of the putative involvement of two intestine‐specific transcription factors, CDX1 and CDX2, in the pathogenesis of gastric IM and gastric carcinoma shows that aberrant expression of CDX 1 andCDX2 is consistently observed in IM and in a subset of gastrics carcinomas.
Journal ArticleDOI
Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen
Nuno T. Marcos,Sandra Pinho,Catarina Grandela,Andrea Cruz,Bénédicte Samyn-Petit,Anne Harduin-Lepers,Raquel Almeida,Filipe Santos Silva,Vanessa A. Morais,Júlia Costa,Jan Kihlberg,Henrik Clausen,Celso A. Reis +12 more
TL;DR: In this article, the authors characterized two sialyltransferases, CMP-Neu5Ac:GalNAc-R alpha2,6-sialyl transferase (ST6Galnac)-I and ST6Gal NAc-II, that are candidate enzymes for Sialyl-Tn synthases and showed that both enzymes showed similar substrate specificity toward glycoproteins and GalNAcalpha-O-Ser/Thr glycopeptides.
Journal ArticleDOI
Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.
Patrícia Mesquita,Nicolas Jonckheere,Raquel Almeida,Marie-Paule Ducourouble,Jacinta Serpa,Elisabete Silva,Pascal Pigny,Filipe Santos Silva,Celso A. Reis,Debra G. Silberg,Isabelle Van Seuningen,Leonor David +11 more
TL;DR: It is demonstrated that Cdx-2 activates the expression of MUC2 mucin gene in gastric cells, inducing an intestinal transdifferentiation phenotype that parallels what is observed both in intestinal metaplasia and some gastric carcinomas.