Raquel Gabarró

TL;DR: Encouraging results suggest that further enhancement of these structures may yield candidates suitable for consideration as new therapeutics for the treatment of malaria, and provide strong support for the validity of targeting the Plasmodium glycolytic pathway and LDH in the search for novel anti-malarials.

TL;DR: A novel method has been devised to study the metabolome and lipidome of Leishmania donovani axenic amastigotes treated with miltefosine, which indicates that SLs and ergosterol are important for milteFosine sensitivity and, perhaps, MoA.

TL;DR: These antifolates have potent activity against Mtb and represent good starting points for improvement that could lead to in vivo efficacy studies, and are paired with knowledge and tools developed in academia with the infrastructure and chemistry resources of a large pharmaceutical company.

TL;DR: In this article, the authors discuss the published data and recent developments in the research area of bromodomains in parasitic protozoa and further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launch drug discovery campaigns to identify and develop antiparasite drugs that can offer differentiated mechanisms of action.

TL;DR: The power of metabolomics is shown in comparing effects on metabolism of 28 different candidate treatments for Leishmaniasis, and principal components analysis was used to cluster compounds on potential mode of action, offering a medium throughput screening approach in drug selection/prioritization.