P
Paul W. Denny
Researcher at Durham University
Publications - 68
Citations - 3176
Paul W. Denny is an academic researcher from Durham University. The author has contributed to research in topics: Leishmania mexicana & Sphingolipid. The author has an hindex of 25, co-authored 63 publications receiving 2920 citations. Previous affiliations of Paul W. Denny include Queen's University & Imperial College London.
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Journal ArticleDOI
A Plastid of Probable Green Algal Origin in Apicomplexan Parasites
Sabine Köhler,Charles F. Delwiche,Paul W. Denny,Lewis G. Tilney,Paul Webster,R. J. M. Wilson,Jeffrey D. Palmer,David S. Roos +7 more
TL;DR: Observations indicate that the Apicomplexa acquired a plastid by secondary endosymbiosis, probably from a green alga.
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Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum.
Robert J.M. Wilson,Paul W. Denny,Peter R. Preiser,Kaveri Rangachari,Roberts K,Roy A,Whyte A,Malcolm Strath,Daphne J. Moore,P. W. Moore,D. H. Williamson +10 more
TL;DR: The complete gene map described here includes genes for duplicated large and small subunit rRNAs, 25 species of tRNA, three subunits of a eubacterial RNA polymerase, 17 ribosomal proteins, and a translation elongation factor.
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Acylation-dependent protein export in Leishmania.
TL;DR: The data suggest that HASPB is a representative of a novel class of proteins whose translocation onto the surface of eukaryotic cells is dependent upon a “non-classical” pathway involving N-myristoylation/palmitoylation.
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Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.
Rachel Zufferey,Simon Allen,Tamara Barron,Deborah R. Sullivan,Paul W. Denny,Igor C. Almeida,Deborah F. Smith,Salvatore J. Turco,Michael A. J. Ferguson,Stephen M. Beverley +9 more
TL;DR: These findings counter current proposals that GIPLs are required for amastigote survival in the mammalian host or that parasite lyso-alkyl or alkylacyl-GPI anchors are solely responsible for inhibition of macrophage activation.
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GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida.
TL;DR: It is shown that GPI‐anchored parasite macro‐molecules (but not the dual acylated Leishmania surface protein) are enriched in a sphingolipid/sterol‐rich fraction resistant to cold detergent extraction, consistent with the presence of functional lipid rafts in these ancient, highly polarised organisms.