R
Raspudin Saleem-Batcha
Researcher at University of Freiburg
Publications - 18
Citations - 545
Raspudin Saleem-Batcha is an academic researcher from University of Freiburg. The author has contributed to research in topics: Effector & Immune receptor. The author has an hindex of 8, co-authored 15 publications receiving 436 citations. Previous affiliations of Raspudin Saleem-Batcha include University of Lübeck & Indian Institute of Science.
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Journal ArticleDOI
Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization
Andrea Sánchez-Vallet,Andrea Sánchez-Vallet,Raspudin Saleem-Batcha,Anja Kombrink,Guido Hansen,Dirk-Jan Valkenburg,Bart P. H. J. Thomma,Jeroen R. Mesters +7 more
TL;DR: Structural analysis of the LysM effector Ecp6 of the fungal tomato pathogen Cladosporium fulvum reveals a novel mechanism for chitin binding, mediated by intrachain LysM dimerization, leading to a chitIn-binding groove that is deeply buried in the effector protein.
Journal ArticleDOI
Molecular dissection of the mycobacterial stringent response protein Rel
TL;DR: Rel protein from Mycobacterium smegmatis, which is highly homologous to M. tuberculosis Rel, is functional even in the absence of ribosome and uncharged tRNA, and the unique cysteine, of six present in Rel, required for tRNA‐mediated synthesis of ppGpp is identified.
Journal ArticleDOI
ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria.
Ezequiel Wexselblatt,Jehoshua Katzhendler,Raspudin Saleem-Batcha,Guido Hansen,Rolf Hilgenfeld,Gad Glaser,Roee Reuven Vidavski +6 more
TL;DR: A prominent feature of the stringent response is the accumulation of two unusual phosphorylated derivatives of GTP and GDP within a few seconds after the onset of amino-acid starvation, which appears to be a very attractive approach for the development of novel antibacterial agents.
Journal ArticleDOI
Aminoperoxide adducts expand the catalytic repertoire of flavin monooxygenases.
Arne Matthews,Raspudin Saleem-Batcha,Jacob N. Sanders,Frederick Stull,K. N. Houk,Robin Teufel +5 more
TL;DR: It is demonstrated that overlooked flavin-N5-oxygen adducts are more widespread and may facilitate versatile chemistry, thus upending the notion that flavin monooxygenases exclusively function as nature’s equivalents to organic peroxides in synthetic chemistry.
Journal ArticleDOI
Enzymatic control of dioxygen binding and functionalization of the flavin cofactor.
Raspudin Saleem-Batcha,Frederick Stull,Jacob N. Sanders,Bradley S. Moore,Bruce A. Palfey,K. N. Houk,Robin Teufel +6 more
TL;DR: This study unambiguously demonstrates how enzymes may control the O 2 functionalization of an organic cofactor as prerequisite for oxidative catalysis and provides crucial knowledge for future rational design of O 2 -reactive enzymes.