R
Raul Catena
Researcher at University of Zurich
Publications - 30
Citations - 2456
Raul Catena is an academic researcher from University of Zurich. The author has contributed to research in topics: Cancer & Mass cytometry. The author has an hindex of 21, co-authored 30 publications receiving 2043 citations. Previous affiliations of Raul Catena include University of Navarra & Cornell University.
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Journal ArticleDOI
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data.
Denis Schapiro,Hartland W. Jackson,Swetha Raghuraman,Jana R. Fischer,Vito R T Zanotelli,Daniel Schulz,Charlotte Giesen,Raul Catena,Zsuzsanna Varga,Bernd Bodenmiller +9 more
TL;DR: This work has developed an open-source, computational histology topography cytometry analysis toolbox (histoCAT) to enable interactive, quantitative, and comprehensive exploration of individual cell phenotypes, cell–cell interactions, microenvironments, and morphological structures within intact tissues.
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Alternative splicing: an emerging topic in molecular and clinical oncology
TL;DR: The current knowledge on the mechanisms governing abnormal alternativesplicing in cancer and the biological consequences associated with the alteration of splicing in some relevant cancer-related genes are summarized.
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Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition
Dingcheng Gao,Natasha Joshi,Hyejin Choi,Seongho Ryu,Mary Hahn,Raul Catena,Helen Sadik,Pedram Argani,Patrick L. Wagner,Linda T. Vahdat,Jeffrey L. Port,Brendon M. Stiles,Saraswati Sukumar,Nasser K. Altorki,Shahin Rafii,Vivek Mittal +15 more
TL;DR: It is suggested that selectively targeting tumor-elicited myeloid cells or versican represents a potential therapeutic strategy for combating metastatic disease.
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Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes
Alexa Burger,Helen Lindsay,Helen Lindsay,Anastasia Felker,Christopher P. Hess,Carolin Anders,Elena Chiavacci,Jonas Zaugg,Lukas M. Weber,Lukas M. Weber,Raul Catena,Martin Jinek,Mark D. Robinson,Mark D. Robinson,Christian Mosimann +14 more
TL;DR: The results establish that optimally solubilized, in vitro assembled fluorescent Cas9-sgRNA RNPs provide a reproducible reagent for direct and scalable loss-of-function studies and applications beyond zebrafish experiments that require maximal DNA cutting efficiency in vivo.
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Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.
Tina El Rayes,Raul Catena,Sharrell Lee,Marcin Stawowczyk,Natasha Joshi,Claudia Fischbach,Charles A. Powell,Andrew J. Dannenberg,Nasser K. Altorki,Dingcheng Gao,Vivek Mittal +10 more
TL;DR: It is shown that extrinsic inflammation in the lungs leads to the recruitment of bone marrow-derived neutrophils, which degranulate azurophilic granules to release the Ser proteases, elastase and cathepsin G, resulting in the proteolytic destruction of the antitumorigenic factor thrombospondin-1 (Tsp-1).