Rayetta Henderson

TL;DR: The evidence generally supports that consumption of up to 400 mg caffeine/day in healthy adults is not associated with overt, adverse cardiovascular effects, behavioral effects, reproductive and developmental effects, acute effects, or bone status and a shift in caffeine research to focus on characterizing effects in sensitive populations is supported.

TL;DR: This first systematic map of the safety-related information available for CBD in the peer-reviewed literature is developed and reproductive and developmental toxicity was identified as a data gap that warrants conducting a well-designed, guideline-compliant reproductive toxicity study on CBD.

TL;DR: In this paper , the potential for toxicity following repeated oral exposure to hemp-derived CBD isolate was evaluated in male and female Sprague Dawley rats for 14 and 90 days at concentrations up to 150 and 140 mg/kg-bw/d, respectively.

TL;DR: In this article , the authors conducted an OECD Test Guideline 421 GLP-compliant study in rats, with extended postnatal dosing and hormone analysis, where hemp-derived CBD isolate (0, 30, 100, or 300 mg/kg-bw/d) was administered orally.

TL;DR: In this article , the genotoxic potential of a pure CBD isolate was investigated in a battery of three genotoxicity assays conducted according to OECD testing guidelines, and the results indicated that CBD is unlikely to pose a genotoxin hazard.