R
Raymond J. Apple
Researcher at Hoffmann-La Roche
Publications - 37
Citations - 5818
Raymond J. Apple is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cervical intraepithelial neoplasia & Human leukocyte antigen. The author has an hindex of 27, co-authored 37 publications receiving 5627 citations.
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Journal ArticleDOI
Improved Amplification of Genital Human Papillomaviruses
Patti E. Gravitt,Cheri L. Peyton,T. Q. Alessi,Cosette M. Wheeler,François Coutlée,Allan Hildesheim,Mark Schiffman,David R. Scott,Raymond J. Apple +8 more
TL;DR: The redesigned MY09/11 primers were redesigned to increase the sensitivity of amplification across the type spectrum by using the same primer binding regions in the L1 open reading frame, and affords an increase in type-specific amplification sensitivity over that of the standard MY 09/11 primer system.
Journal ArticleDOI
Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection
Richard A. Kaslow,Mary Carrington,Raymond J. Apple,Lawrence P. Park,Alvaro Muñoz,A. J. Saah,James J. Goedert,Cheryl A. Winkler,Stephen J. O'Brien,Charles R. Rinaldo,Roger Detels,William A. Blattner,John P. Phair,Henry A. Erlich,Dean L. Mann +14 more
TL;DR: An HLA profile was produced that predicted time from HIV–1 infection to the onset of AIDS and support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.
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Genotyping of 27 Human Papillomavirus Types by Using L1 Consensus PCR Products by a Single-Hybridization, Reverse Line Blot Detection Method
TL;DR: The primary advantage of the strip-based detection system is the ability to rapidly genotype HPVs present in genital samples with high sensitivity and specificity, minimizing the likelihood of misclassification.
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HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.
Raymond J. Apple,Henry A. Erlich,William Klitz,M. Michele Manos,Thomas M. Becker,Cosette M. Wheeler +5 more
TL;DR: Results suggest that specific HLA class II haplotypes may influence the immune response to specific HPV–encoded epitopes and affect the risk of cervical neoplasia.
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High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV study.
Mark H. Stoler,Thomas C. Wright,Abha Sharma,Raymond J. Apple,Karen Gutekunst,Teresa L. Wright +5 more
TL;DR: The cobas 4800 HPV Test demonstrated performance comparable to the Hybrid Capture 2 test (QIAGEN) for the detection of cervical intraepithelial neoplasia (CIN) grade 2 or worse and grade 3 or worse.