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Raymond J. Apple

Researcher at Hoffmann-La Roche

Publications -  37
Citations -  5818

Raymond J. Apple is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cervical intraepithelial neoplasia & Human leukocyte antigen. The author has an hindex of 27, co-authored 37 publications receiving 5627 citations.

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Improved Amplification of Genital Human Papillomaviruses

TL;DR: The redesigned MY09/11 primers were redesigned to increase the sensitivity of amplification across the type spectrum by using the same primer binding regions in the L1 open reading frame, and affords an increase in type-specific amplification sensitivity over that of the standard MY 09/11 primer system.
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Genotyping of 27 Human Papillomavirus Types by Using L1 Consensus PCR Products by a Single-Hybridization, Reverse Line Blot Detection Method

TL;DR: The primary advantage of the strip-based detection system is the ability to rapidly genotype HPVs present in genital samples with high sensitivity and specificity, minimizing the likelihood of misclassification.
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HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.

TL;DR: Results suggest that specific HLA class II haplotypes may influence the immune response to specific HPV–encoded epitopes and affect the risk of cervical neoplasia.
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High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV study.

TL;DR: The cobas 4800 HPV Test demonstrated performance comparable to the Hybrid Capture 2 test (QIAGEN) for the detection of cervical intraepithelial neoplasia (CIN) grade 2 or worse and grade 3 or worse.