R
Reaz Uddin
Researcher at University of Karachi
Publications - 82
Citations - 1612
Reaz Uddin is an academic researcher from University of Karachi. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 52 publications receiving 1141 citations. Previous affiliations of Reaz Uddin include University of Illinois at Chicago & University of New South Wales.
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Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach.
TL;DR: Computational drug design methods were applied to identify Chymotrypsin-like protease inhibitors from FDA approved antiviral drugs and an in-house database of natural and drug-like compounds of synthetic origin and results indicate that the identified compounds can inhibit the function of Chymosorbic protease of Coronavirus.
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Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.
Imtiaz Khan,Sajid Ali,Shahid Hameed,Nasim Hasan Rama,Muhammad Tahir Hussain,Abdul Wadood,Reaz Uddin,Zaheer Ul-Haq,Ajmal Khan,Sajjad Ali,M. Iqbal Choudhary +10 more
TL;DR: N-(2,4-Dimethylphenyl)-5-(4-nitrophenyl)-1,3, 4-thiadiazol-2-amine (9h) showed excellent antioxidant activity more than the standard drug whereas 4,5-disubstituted-2,8-dihydro-3H-1,2-4-triazole-3-thione exhibited potent urease inhibitory activities.
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5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.
Subash Velaparthi,Michael Brunsteiner,Reaz Uddin,Baojie Wan,Scott G. Franzblau,Pavel A. Petukhov +5 more
TL;DR: A series of 5- tert-butyl- N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo-3-carboxamide derivatives are presented as novel potent Mycobacterium tuberculosis PS inhibitors, their in silico molecular design, synthesis, and inhibitory activity.
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Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents.
Fazal Rahim,Khalid Zaman,Hayat Ullah,Muhammad Taha,Abdul Wadood,Muhammad Tariq Javed,Wajid Rehman,Muhammad Ashraf,Reaz Uddin,Imad Uddin,Humna Asghar,Aftab Ahmad Khan,Khalid Mohammed Khan +12 more
TL;DR: Eight derivatives of 4-Thiazolidinone analogs 1-20 showed outstanding urease inhibitory potential, which is better than the standard thiourea, and the remaining analogs showed good to excellent u rerease inhibition.
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Binding mode analysis, dynamic simulation and binding free energy calculations of the MurF ligase from Acinetobacter baumannii.
TL;DR: The present results indicate that the screened compound 114 may act as a parent structure for designing potent derivatives against AbMurF in specific and MurF of other bacterial pathogens in general.