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Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.
Imtiaz Khan,Sajid Ali,Shahid Hameed,Nasim Hasan Rama,Muhammad Tahir Hussain,Abdul Wadood,Reaz Uddin,Zaheer Ul-Haq,Ajmal Khan,Sajjad Ali,M. Iqbal Choudhary +10 more
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TLDR
N-(2,4-Dimethylphenyl)-5-(4-nitrophenyl)-1,3, 4-thiadiazol-2-amine (9h) showed excellent antioxidant activity more than the standard drug whereas 4,5-disubstituted-2,8-dihydro-3H-1,2-4-triazole-3-thione exhibited potent urease inhibitory activities.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2010-11-01. It has received 267 citations till now.read more
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Recent researches in triazole compounds as medicinal drugs.
TL;DR: This work systematically reviewed the recent researches and developments of the whole range of triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic, anticonvulsant, antiparasitic, antidiabetic and anti-obesitic.
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1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry
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Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: synthetic approaches and multifarious applications.
TL;DR: This article is an effort to summarize recent developments in the environmentally benign synthetic methods providing access to quinazoline andQuinazolinone scaffolds with promising biological potential and discuss potential future directions on the development of more potent and specific analogues for various biological targets.
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Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue
TL;DR: Recent developments in the eco-friendly and green procedures for the construction of highly challenging and potentially bioactive quinazoline and quinzolinone compounds are recapitulate in order to help medicinal chemists in designing and synthesizing novel and potent compounds for the treatment of different disorders.
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Understanding the chemistry behind the antioxidant activities of butylated hydroxytoluene (BHT): a review.
Wageeh A. Yehye,Noorsaadah Abdul Rahman,Azhar Ariffin,Sharifah Bee Abd Hamid,Abeer A. Alhadi,Farkaad A. Kadir,Marzieh Yaeghoobi +6 more
TL;DR: The strategy involved investigation on understanding the chemistry behind the antioxidant activities of BHT, whether through hydrogen or electron transfer mechanism to enable promising anti-oxidant candidates to be synthesized.
References
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Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements
TL;DR: Methods available for the measurement of antioxidant capacity are reviewed, presenting the general chemistry underlying the assays, the types of molecules detected, and the most important advantages and shortcomings of each method.
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Mitochondrial free radical generation, oxidative stress, and aging.
TL;DR: In this article, the authors reviewed the mitochondrial rates of production and steady state levels of reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes.
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Free radical scavenging activity of an aqueous extract of potato peel
TL;DR: In this paper, the antioxidant potency of freeze-dried aqueous extract of potato peel was investigated employing various established in vitro systems, such as lipid peroxidation in rat liver homogenate, 1, 1-diphenyl-2-picrylhydrazyl (DPPH)/superoxide/hydroxyl radical scavenging, reducing power, and iron ion chelation.
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Role of reactive aldehyde in cardiovascular diseases.
TL;DR: The protein-bound aldehydes can be detected as constituents not only in in vitro oxidized low-density lipoproteins but also in animal models of atherosclerosis and in human patients with increased risk factors or clinical manifestations of Atherosclerosis, indicating that they could indeed be involved in the caldiovascular pathology.