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Rebecca Earnest
Researcher at Yale University
Publications - 27
Citations - 4715
Rebecca Earnest is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 19 publications receiving 2475 citations. Previous affiliations of Rebecca Earnest include Harvard University.
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Journal ArticleDOI
Longitudinal analyses reveal immunological misfiring in severe COVID-19.
Carolina Lucas,Patrick Wong,Jon Klein,Tiago B. R. Castro,Julio Silva,Maria E. Sundaram,Mallory K. Ellingson,Tianyang Mao,Ji Eun Oh,Benjamin Israelow,Takehiro Takahashi,Maria Tokuyama,Peiwen Lu,Arvind Venkataraman,Annsea Park,Subhasis Mohanty,Haowei Wang,Anne L. Wyllie,Chantal B.F. Vogels,Rebecca Earnest,Sarah Lapidus,Isabel M. Ott,Adam J. Moore,M. Catherine Muenker,John Fournier,Melissa Campbell,Camila D. Odio,Arnau Casanovas-Massana,Roy S. Herbst,Albert C. Shaw,Ruslan Medzhitov,Ruslan Medzhitov,Wade L. Schulz,Nathan D. Grubaugh,Charles S. Dela Cruz,Shelli F. Farhadian,Albert I. Ko,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +39 more
TL;DR: A longitudinal analysis of immune responses in patients with moderate or severe COVID-19 identifies a maladapted immune response profile linked to severe disease, as well as early immune signatures that correlate with divergent disease trajectories.
Journal ArticleDOI
Sex differences in immune responses that underlie COVID-19 disease outcomes.
Takehiro Takahashi,Mallory K. Ellingson,Patrick Wong,Benjamin Israelow,Carolina Lucas,Jon Klein,Julio Silva,Tianyang Mao,Ji Eun Oh,Maria Tokuyama,Peiwen Lu,Arvind Venkataraman,Annsea Park,Feimei Liu,Amit Meir,Jonathan Sun,Eric Wang,Arnau Casanovas-Massana,Anne L. Wyllie,Chantal B.F. Vogels,Rebecca Earnest,Sarah Lapidus,Isabel M. Ott,Adam J. Moore,Albert C. Shaw,John Fournier,Camila D. Odio,Shelli F. Farhadian,Charles S. Dela Cruz,Nathan D. Grubaugh,Wade L. Schulz,Aaron M. Ring,Albert I. Ko,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +35 more
TL;DR: Examination of sex differences in viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines and blood-cell phenotyping in patients with moderate COVID-19 found that a poor T cell response negatively correlated with patients’ age and was associated with worse disease outcome in male patients, but not in female patients.
Journal ArticleDOI
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.
Anne L. Wyllie,John Fournier,Arnau Casanovas-Massana,Melissa Campbell,Maria Tokuyama,Pavithra Vijayakumar,Joshua L. Warren,Bertie Geng,M. Catherine Muenker,Adam J. Moore,Chantal B.F. Vogels,Mary E. Petrone,Isabel M. Ott,Peiwen Lu,Arvind Venkataraman,Alice Lu-Culligan,Jonathan Klein,Rebecca Earnest,Michael Simonov,Rupak Datta,Ryan Handoko,Nida Naushad,Lorenzo R. Sewanan,Jordan Valdez,Elizabeth B. White,Sarah Lapidus,Chaney C. Kalinich,Xiaodong Jiang,Daniel J. Kim,Eriko Kudo,Melissa M. Linehan,Tianyang Mao,Miyu Moriyama,Ji Eun Oh,Annsea Park,Julio Silva,Eric Song,Takehiro Takahashi,Manabu Taura,Orr-El Weizman,Patrick Wong,Yexin Yang,Santos Bermejo,Camila D. Odio,Saad B. Omer,Charles S. Dela Cruz,Shelli F. Farhadian,Richard A. Martinello,Akiko Iwasaki,Nathan D. Grubaugh,Albert I. Ko +50 more
TL;DR: Investigators report that saliva specimens and nasopharyngeal swab specimens had similar sensitivity in the detection of SARS-CoV-2 Infection.
Journal ArticleDOI
Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.
Chantal B.F. Vogels,Anderson F. Brito,Anne L. Wyllie,Joseph R. Fauver,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Arnau Casanovas-Massana,M. Catherine Muenker,Adam J. Moore,Jonathan Klein,Peiwen Lu,Alice Lu-Culligan,Xiaodong Jiang,Daniel J. Kim,Eriko Kudo,Tianyang Mao,Miyu Moriyama,Ji Eun Oh,Annsea Park,Julio Silva,Eric Song,Takehiro Takahashi,Manabu Taura,Maria Tokuyama,Arvind Venkataraman,Orr-El Weizman,Patrick Wong,Yexin Yang,Nagarjuna R. Cheemarla,Elizabeth B. White,Sarah Lapidus,Rebecca Earnest,Bertie Geng,Pavithra Vijayakumar,Camila D. Odio,John Fournier,Santos Bermejo,Shelli F. Farhadian,Charles S. Dela Cruz,Akiko Iwasaki,Akiko Iwasaki,Albert I. Ko,Marie L. Landry,Ellen F. Foxman,Nathan D. Grubaugh +45 more
TL;DR: Comparisons of RT–qPCR analytical efficiency and sensitivity show that all primer–probe sets can be used to detect SARS-CoV-2 at 500 viral RNA copies per reaction.
Posted ContentDOI
Analytical sensitivity and efficiency comparisons of SARS-COV-2 qRT-PCR assays
Chantal B.F. Vogels,Anderson F. Brito,Anne L. Wyllie,Joseph R. Fauver,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Arnau Casanovas-Massana,M. Catherine Muenker,Adam J. Moore,Jonathan Klein,Peiwen Lu,Alice Lu-Culligan,Xiaodong Jiang,Daniel J. Kim,Eriko Kudo,Tianyang Mao,Miyu Moriyama,Ji Eun Oh,Annsea Park,Julio Silva,Eric Song,Takehiro Takehashi,Manabu Taura,Maria Tokuyama,Arvind Venkataraman,Orr-El Weizman,Patrick Wong,Yexin Yang,Nagarjuna R. Cheemarla,Elizabeth B. White,Sarah Lapidus,Rebecca Earnest,Bertie Geng,Pavithra Vijayakumar,Camila D. Odio,John Fournier,Santos Bermejo,Shelli F. Farhadian,Charles S. Dela Cruz,Akiko Iwasaki,Albert I. Ko,Marie-Louise Landry,Ellen F. Foxman,Nathan D. Grubaugh +44 more
TL;DR: It is shown that all primer-probe sets can be used to detect SARS-CoV-2 at 500 virus copies per reaction, except for the RdRp-SARSr (Charite) confirmatory primer-Probe set which has low sensitivity.