Rebecca H. R. Ward

TL;DR: The CD4-gp120 interaction is an obvious target for AIDS therapeutics because it leads to progressive destruction of the CD4+ subset of T lymphocytes, resulting in immunodeficiency and AIDS.

TL;DR: The findings suggest that NUDT15 genotyping may be considered prior to initiation of thiopurine therapy; however, further study including additional validation in independent cohorts is required.

TL;DR: Two children from two unrelated families had a history of recurrent bacterial infections, and their neutrophils were shown to have deficient phagocytic and respiratory responses and possible deficiencies in chemotaxis or adherence, which may have been one of the reasons for their increased susceptibility to bacterial infections.

TL;DR: It is reported that pretreatment with CD4–IgG can prevent the infection of chimpanzees with HIV-1, suggesting that it may be possible to set up an immune state in a fetus before HIV transfer occurs, thus preventing infection.

TL;DR: In this paper, a method for the prevention or treatment of inflammatory bowel disease by administering an interferon-γ inhibitor was proposed, and pharmaceutical compositions and bispecific molecules useful in such method were discussed.