G
Gareth J. Walker
Researcher at University of Exeter
Publications - 41
Citations - 1114
Gareth J. Walker is an academic researcher from University of Exeter. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 8, co-authored 33 publications receiving 594 citations. Previous affiliations of Gareth J. Walker include Bristol Royal Infirmary & University Hospitals Bristol NHS Foundation Trust.
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Journal ArticleDOI
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Nicholas A. Kennedy,Nicholas A. Kennedy,Nicholas A. Kennedy,Graham A. Heap,Harry D Green,Benjamin Hamilton,Claire Bewshea,Gareth J. Walker,Amanda Thomas,Rachel Nice,Mandy H Perry,Sonia Bouri,Neil Chanchlani,Neel Heerasing,Peter Hendy,Simeng Lin,Daniel R. Gaya,J R Fraser Cummings,J R Fraser Cummings,Christian P. Selinger,Charlie W. Lees,Charlie W. Lees,Ailsa L. Hart,Miles Parkes,Shaji Sebastian,John C Mansfield,Peter M. Irving,James O. Lindsay,Richard K Russell,Timothy J. McDonald,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie W. Lees,Gareth R. Jones,James W Hart,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil Shah,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C. Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +160 more
TL;DR: Clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal are identified.
Journal ArticleDOI
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease
Aleksejs Sazonovs,Nicholas A Kennedy,Nicholas A Kennedy,Loukas Moutsianas,Graham A. Heap,Graham A. Heap,Daniel L. Rice,Mark Reppell,Claire Bewshea,Neil Chanchlani,Neil Chanchlani,Gareth J. Walker,Gareth J. Walker,Mandy H Perry,Timothy J. McDonald,Charlie W. Lees,J R Fraser Cummings,J R Fraser Cummings,Miles Parkes,John C. Mansfield,Peter M. Irving,Jeffrey C. Barrett,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Carl A. Anderson,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie Lees,Gareth T. Jones,James W Hart,Daniel R. Gaya,Richard K. Russell,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Shaji Sebastian,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Christian P. Selinger,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O. Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil P. Shah,Sonia Bouri,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Fraser Cummings,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +159 more
TL;DR: In an observational study, a genome-wide significant association between HLA-DQA1*05 and the development of antibodies against anti-TNF agents is found and a randomized controlled biomarker trial is required to determine whether pretreatment testing for HLA*05 improves patient outcomes by helping physicians select anti- TNF and combination therapies.
Journal ArticleDOI
Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.
Gareth J. Walker,Gareth J. Walker,James W. Harrison,Graham A. Heap,Graham A. Heap,Michiel Voskuil,Vibeke Andersen,Carl A. Anderson,Ashwin N. Ananthakrishnan,Jeffrey C. Barrett,Laurent Beaugerie,Claire Bewshea,Andy Cole,Fraser Cummings,Mark J. Daly,Pierre Ellul,Richard N. Fedorak,Eleonora A. M. Festen,Timothy H. Florin,Daniel R. Gaya,Jonas Halfvarson,Ailsa L. Hart,Neel Heerasing,Neel Heerasing,Peter Hendy,Peter Hendy,Peter M. Irving,Samuel E. Jones,Jukka Koskela,James O. Lindsay,John C. Mansfield,Dermot P.B. McGovern,Miles Parkes,Richard Pollok,Subramaniam Ramakrishnan,David S. Rampton,Manuel A. Rivas,Richard K Russell,Michael Schultz,Shaji Sebastian,Philippe Seksik,Abhey Singh,Kenji So,Harry Sokol,Kavitha Subramaniam,Anthony Todd,Vito Annese,Rinse K. Weersma,Ramnik J. Xavier,Rebecca H. R. Ward,Michael N. Weedon,James R Goodhand,James R Goodhand,Nicholas A. Kennedy,Nicholas A. Kennedy,Tariq Ahmad,Tariq Ahmad +56 more
TL;DR: The findings suggest that NUDT15 genotyping may be considered prior to initiation of thiopurine therapy; however, further study including additional validation in independent cohorts is required.
Journal ArticleDOI
Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn's disease
Neel Heerasing,Beth Thompson,Peter Hendy,Graham A. Heap,Gareth J. Walker,Rob Bethune,Stephen Mansfield,Christopher Calvert,Nicholas A. Kennedy,Tariq Ahmad,James R Goodhand +10 more
TL;DR: Few studies have reported the systematic use of exclusive enteral nutrition in the perioperative setting, and the need for further studies is still to be determined.
Journal ArticleDOI
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
Chase C. Suiter,Takaya Moriyama,Kenneth A. Matreyek,Wentao Yang,Emma Rose Scaletti,Emma Rose Scaletti,Rina Nishii,Wenjian Yang,Keito Hoshitsuki,Minu Singh,Amita Trehan,Chris Parish,Colton Smith,Lie Li,Deepa Bhojwani,Liz Y P Yuen,Chi Kong Li,C. H. Li,Yung-Li Yang,Gareth J. Walker,Gareth J. Walker,James R Goodhand,James R Goodhand,Nicholas A. Kennedy,Nicholas A. Kennedy,Federico Antillon Klussmann,Smita Bhatia,Mary V. Relling,Motohiro Kato,Hiroki Hori,Prateek Bhatia,Tariq Ahmad,Tariq Ahmad,Allen Eng Juh Yeoh,Pål Stenmark,Pål Stenmark,Douglas M. Fowler,Douglas M. Fowler,Jun J. Yang +38 more
TL;DR: A massively parallel assay was developed to preemptively characterize 91.8% of all possible missense variants in NUDT15, providing a comprehensive reference of variant function and vastly improving the ability to implement pharmacogenetics-guided thiopurine treatment individualization.