L
Laurent Beaugerie
Researcher at University of Paris
Publications - 54
Citations - 2755
Laurent Beaugerie is an academic researcher from University of Paris. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 18, co-authored 54 publications receiving 2131 citations. Previous affiliations of Laurent Beaugerie include Pierre-and-Marie-Curie University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
Henri Duboc,Sylvie Rajca,Sylvie Rajca,Dominique Rainteau,Dominique Rainteau,David Benarous,Marie-Anne Maubert,Marie-Anne Maubert,Elodie Quervain,Elodie Quervain,Ginette Thomas,Ginette Thomas,Véronique Barbu,Lydie Humbert,Lydie Humbert,Guillaume Despras,Chantal Bridonneau,Fabien Dumetz,Jean-Pierre Grill,Jean-Pierre Grill,Joëlle Masliah,Joëlle Masliah,Laurent Beaugerie,Laurent Beaugerie,Jacques Cosnes,Jacques Cosnes,Olivier Chazouillères,Raoul Poupon,Claude Wolf,Jean-Maurice Mallet,Philippe Langella,Germain Trugnan,Germain Trugnan,Harry Sokol,Harry Sokol,Philippe Seksik,Philippe Seksik +36 more
TL;DR: Altered BA transformation in the gut lumen can erase the anti-inflammatory effects of some BA species on gut epithelial cells and could participate in the chronic inflammation loop of IBD.
Journal ArticleDOI
Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease
Laurent Peyrin Biroulet,Kiarash Khosrotehrani,Fabrice Carrat,Anne Marie Bouvier,Jean Baptiste Chevaux,Tabassome Simon,F. Carbonnel,Jean-Frederic Colombel,Jean Louis Dupas,Philippe Godeberge,Jean-Pierre Hugot,Marc Lémann,Stéphane Nahon,Jean Marc Sabate,Gilbert Tucat,Laurent Beaugerie +15 more
TL;DR: Ooing and past exposure to thiopurines significantly increases the risk of NMSC in patients with IBD, even before the age of 50 years, and these patients should be protected against UV radiation and receive lifelong dermatologic screening.
Journal ArticleDOI
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations.
Gert Van Assche,Axel Dignass,Bernd Bokemeyer,Silvio Danese,Paolo Gionchetti,Gabriele Moser,Laurent Beaugerie,Fernando Gomollón,Winfried Häuser,Klaus Herrlinger,Bas Oldenburg,Julián Panés,Francisco Portela,Gerhard Rogler,Jürgen Stein,Herbert Tilg,Simon Travis,James O. Lindsay +17 more
TL;DR: Pouchitis is a non-specific inflammation of the ileal reservoir and the most common complication of IPAA in patients with UC, and may be caused by conditions other than pouchitis, including Crohn's disease of the pouch and an irritable pouch.
Journal ArticleDOI
Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.
Gareth J. Walker,Gareth J. Walker,James W. Harrison,Graham A. Heap,Graham A. Heap,Michiel Voskuil,Vibeke Andersen,Carl A. Anderson,Ashwin N. Ananthakrishnan,Jeffrey C. Barrett,Laurent Beaugerie,Claire Bewshea,Andy Cole,Fraser Cummings,Mark J. Daly,Pierre Ellul,Richard N. Fedorak,Eleonora A. M. Festen,Timothy H. Florin,Daniel R. Gaya,Jonas Halfvarson,Ailsa L. Hart,Neel Heerasing,Neel Heerasing,Peter Hendy,Peter Hendy,Peter M. Irving,Samuel E. Jones,Jukka Koskela,James O. Lindsay,John C. Mansfield,Dermot P.B. McGovern,Miles Parkes,Richard Pollok,Subramaniam Ramakrishnan,David S. Rampton,Manuel A. Rivas,Richard K Russell,Michael Schultz,Shaji Sebastian,Philippe Seksik,Abhey Singh,Kenji So,Harry Sokol,Kavitha Subramaniam,Anthony Todd,Vito Annese,Rinse K. Weersma,Ramnik J. Xavier,Rebecca H. R. Ward,Michael N. Weedon,James R Goodhand,James R Goodhand,Nicholas A. Kennedy,Nicholas A. Kennedy,Tariq Ahmad,Tariq Ahmad +56 more
TL;DR: The findings suggest that NUDT15 genotyping may be considered prior to initiation of thiopurine therapy; however, further study including additional validation in independent cohorts is required.
Journal ArticleDOI
Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease.
Harry Sokol,Laurent Beaugerie,Marc Maynadié,David Laharie,Jean-Louis Dupas,Bernard Flourié,Eric Lerebours,Laurent Peyrin-Biroulet,Matthieu Allez,Tabassome Simon,Fabrice Carrat,Nicole Brousse +11 more
TL;DR: Patients with IBD have an increased risk of developing primary intestinal lymphoproliferative disorders (PILD) and the risk was highest in patients exposed to thiopurines, while it did not reach statistical significance in patients naïve toThiopurine exposure.