Rebecca J. Morris

TL;DR: It is shown that bulge cells in adult mice generate all epithelial cell types within the intact follicle and hair during normal hair follicle cycling and provide potential targets for the treatment of hair loss and other disorders of skin and hair.

TL;DR: It is shown that ablation of bulge cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kinase leads to complete loss of hair follicles but survival of the epidermis, indicating that bulge stem cells respond rapidly to epidermal wounding by generating short-lived 'transient amplifying' cells responsible for acute wound repair.

TL;DR: This work is the first to demonstrate that CD34 is a specific marker of bulge cell keratinocytes in the cutaneous epithelium, potentially providing a tool for the study of carcinogen target cells, gene therapy, and tissue engineering applications.

TL;DR: Cellular topography within the highly polarized surface epithelia can be used to identify the location of the stem cells and in some instances, this can be quite precise and allows the characteristics of stem cells to be studied.

TL;DR: It is demonstrated that murine dorsal keratinocytes characterized by their high levels of alpha(6) integrin and low to undetectable expression of the transferrin receptor (CD71) termed alpha(bri)CD71(dim) cells, are enriched for epithelial stem cells.