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Yaping Liu
Researcher at Merck & Co.
Publications - 16
Citations - 4114
Yaping Liu is an academic researcher from Merck & Co.. The author has contributed to research in topics: Hair follicle & Stem cell. The author has an hindex of 13, co-authored 15 publications receiving 3812 citations. Previous affiliations of Yaping Liu include University of Pennsylvania.
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Journal ArticleDOI
Capturing and profiling adult hair follicle stem cells
Rebecca J. Morris,Yaping Liu,Lee Marles,Zaixin Yang,Carol S. Trempus,Shulan Li,Jamie S. Lin,Janet A. Sawicki,George Cotsarelis +8 more
TL;DR: It is shown that bulge cells in adult mice generate all epithelial cell types within the intact follicle and hair during normal hair follicle cycling and provide potential targets for the treatment of hair loss and other disorders of skin and hair.
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Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis.
TL;DR: It is shown that ablation of bulge cells by targeting them with a suicide gene encoding herpes simplex virus thymidine kinase leads to complete loss of hair follicles but survival of the epidermis, indicating that bulge stem cells respond rapidly to epidermal wounding by generating short-lived 'transient amplifying' cells responsible for acute wound repair.
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The c8/144b monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells
Stephen Lyle,Melpo Christofidou-Solomidou,Yaping Liu,David E. Elder,Steven M. Albelda,George Cotsarelis +5 more
TL;DR: It is demonstrated that bulge cells possess a stem cell phenotype characterized by their slowly-cycling nature, preferential proliferation at the onset of new hair follicle growth, high level of beta1 integrin expression, and expression of cytokeratin 19.
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Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge
TL;DR: It is found that patterns of K15 expression and promoter activity changed with age and correlated with levels of differentiation within the cutaneous epithelium; less differentiated keratinocytes in the epidermis of the neonatal mouse and in the bulge area of the adult mouse preferentially expressed K15.
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Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
Luis A. Garza,Yaping Liu,Zaixin Yang,Brinda Alagesan,John A. Lawson,Scott M. Norberg,Dorothy E. Loy,Tailun Zhao,Hanz Blatt,David C. Stanton,Lee Carrasco,Gurpreet Ahluwalia,Susan M. Fischer,Garret A. FitzGerald,George Cotsarelis +14 more
TL;DR: PGD2 is defined as an inhibitor of hair growth in AGA and the PGD2-GPR44 pathway is suggested as a potential target for treatment, providing new insight into the pathogenesis of AGA.