Carol S. Trempus

TL;DR: It is shown that bulge cells in adult mice generate all epithelial cell types within the intact follicle and hair during normal hair follicle cycling and provide potential targets for the treatment of hair loss and other disorders of skin and hair.

TL;DR: This work is the first to demonstrate that CD34 is a specific marker of bulge cell keratinocytes in the cutaneous epithelium, potentially providing a tool for the study of carcinogen target cells, gene therapy, and tissue engineering applications.

TL;DR: Optimal fixation protocols for LCM analysis will facilitate the examination of gene expression in specific cell populations, accelerating investigations of the molecular differences responsible for the phenotypic changes observed during carcinogenesis.

TL;DR: This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.

TL;DR: Evidence that ras-mediated tumorigenesis depends on signaling pathways that act preferentially through cyclin D1 is provided, which results in up to an 80% decrease in the development of squamous tumors generated through either grafting of retroviral ras to keratinocytes, phorbol ester treatment of ras transgenic mice, or two-stage carcinogenesis.