Rebecca Mitchell

TL;DR: It is presented that while HCQ is ineffective, Lys05-mediated autophagy inhibition reduces LSCs quiescence and drives myeloid cell expansion, providing a strong rationale for clinical use of second generation autophagic inhibitors as a novel treatment for CML patients with LSC persistence.

TL;DR: It is demonstrated that knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle, which leads to increased oxidative phosphorylation and mitochondrial ROS accumulation.

TL;DR: It is shown that ponatinib-resistant CML cells can acquire BCR-ABL-independent resistance mediated through alternative activation of mTOR, and mTOR inhibition as an alternative therapeutic approach in TKI-resistantCML cells is highlighted.

TL;DR: The test-retest reliability of a new scale for use in a study of the correlates of active travel and overall physical activity in deprived urban neighbourhoods in Glasgow, Scotland contributes to the development of a growing set of tools for investigating the role of perceived environmental characteristics in explaining or mediating patterns of activeTravel and physical activity.

TL;DR: The data show that Axl inhibition has therapeutic potential in BCR-ABL TKI-sensitive as well as -resistant CML and support the need for clinical trials.