P
Pablo Baquero
Researcher at University of Glasgow
Publications - 27
Citations - 993
Pablo Baquero is an academic researcher from University of Glasgow. The author has contributed to research in topics: Stem cell & PI3K/AKT/mTOR pathway. The author has an hindex of 11, co-authored 26 publications receiving 741 citations. Previous affiliations of Pablo Baquero include University of Alcalá & Life Sciences Institute.
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Journal ArticleDOI
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
Elodie M. Kuntz,Pablo Baquero,Alison M. Michie,Karen Dunn,Saverio Tardito,Tessa L. Holyoake,G. Vignir Helgason,Eyal Gottlieb +7 more
TL;DR: It is demonstrated that primitive CML cells rely on upregulated oxidative metabolism for their survival, and combination treatment with imatinib and tigecycline, an antibiotic that inhibits mitochondrial protein translation, selectively eradicates CML LSCs both in vitro and in a xenotransplantation model of human CML.
Journal ArticleDOI
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Sheela A. Abraham,Lisa E. M. Hopcroft,Emma Carrick,Mark E. Drotar,Karen Dunn,Andrew J.K. Williamson,Koorosh Korfi,Pablo Baquero,Laura Park,Mary T. Scott,Francesca Pellicano,Andrew Pierce,Mhairi Copland,Craig Nourse,Sean M. Grimmond,David Vetrie,Anthony D. Whetton,Tessa L. Holyoake +17 more
TL;DR: Perturbation of both p53 and c-Myc, not BCR-ABL1 itself, leads to synergistic kill, differentiation and near elimination of transplantable human LSC in mice, whilst sparing normal HSC.
Journal ArticleDOI
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors
Pablo Baquero,Amy Dawson,Arunima Mukhopadhyay,Elodie M. Kuntz,Rebecca Mitchell,Orianne Olivares,Angela Ianniciello,Mary T. Scott,Karen Dunn,Michael C. Nicastri,Jeffrey D. Winkler,Alison M. Michie,Kevin M. Ryan,Christina Halsey,Eyal Gottlieb,Erin P. Keaney,Leon Murphy,Ravi K. Amaravadi,Tessa L. Holyoake,G. Vignir Helgason +19 more
TL;DR: It is presented that while HCQ is ineffective, Lys05-mediated autophagy inhibition reduces LSCs quiescence and drives myeloid cell expansion, providing a strong rationale for clinical use of second generation autophagic inhibitors as a novel treatment for CML patients with LSC persistence.
Journal ArticleDOI
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells.
Maria Karvela,Pablo Baquero,Elodie M. Kuntz,Arunima Mukhopadhyay,Rebecca Mitchell,Elaine K. Allan,Edmond Chan,Kamil R. Kranc,Bruno Calabretta,Paolo Salomoni,Eyal Gottlieb,Tessa L. Holyoake,G. Vignir Helgason +12 more
TL;DR: It is demonstrated that knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle, which leads to increased oxidative phosphorylation and mitochondrial ROS accumulation.
Journal ArticleDOI
Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition
Rebecca Mitchell,Lisa E. M. Hopcroft,Pablo Baquero,Elaine K. Allan,Kay Hewit,Daniel James,Graham Hamilton,Arunima Mukhopadhyay,Jim O'Prey,Alan Hair,Junia V. Melo,Edmond Chan,Kevin M. Ryan,Véronique Maguer-Satta,Brian J. Druker,Richard E. Clark,Subir Mitra,Pawel Herzyk,Franck E. Nicolini,Paolo Salomoni,Emma Shanks,Bruno Calabretta,Tessa L. Holyoake,G. Vignir Helgason +23 more
TL;DR: It is shown that ponatinib-resistant CML cells can acquire BCR-ABL-independent resistance mediated through alternative activation of mTOR, and mTOR inhibition as an alternative therapeutic approach in TKI-resistantCML cells is highlighted.