Reda F. A. Abdelhameed

TL;DR: In this article, molecular docking, ADME properties and all-atom molecular dynamic simulation, along with two standard antiviral agents (lopinavir and benzopurpurin-4B), were applied to investigate 15 scalaranes sesterterpenes natural compounds, purified from the Red Sea marine sponge Hyrtios erectus, as potential COVID-19 dual-target inhibitors.

TL;DR: This study highlights the potential of A. terreus strain S020 for the industrial production of bioactive terrein on a large scale and the importance of future investigations of these strains to identify the bioactive leads in these fungal extracts.

TL;DR: New neutral benzene-sulfonamide containing compounds were designed, designed, synthesized and biologically evaluated as potent PTP1B inhibitors and showed a high affinity and selectivity to the active site and B-site of PTP 1B holding hydrogen bonding, hydrophobic, and electrostatic interactions.

TL;DR: The ceramides obtained using the approaches described here could be considered as promising lead compounds for the discovery and design of potent anti-choline esterase drug candidates, which would be used for Alzheimer’s eradication.

TL;DR: In this article, the n-hexane fraction of the whole plant of T. sanguinea Vahl was used for the isolation of two glucocerebroside molecular species TSC-1 and tSC-2, one β-sitosteryl-3β-D-glucopyranoside-6′-O-fatty acid ester molecular species, TSS-1, and seven known triterpenes.