Regina Vogel

TL;DR: It is shown that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and shh in placode formation and is essential for fate decisions of skin stem cells: in the absence of beta-Catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate.

TL;DR: The data demonstrate that β-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm.

TL;DR: The results identify a novel intracellular signaling module that synergistically regulates CAFs and CSCs in mammary gland tumors driven by combined activation of Wnt/β-catenin and Hgf/Met signaling in mouse mammary epithelial cells.

TL;DR: It is demonstrated that Gab1 induces different biological responses through the recruitment of distinct effectors and that different modes of recruitment for Gab1 are required in different organs.

TL;DR: A compound-mutant mouse model combining the activation of β-catenin and HGF (Wnt-Met signaling) produced rapidly growing basal mammary gland tumors, and targeting CXCR4 and its upstream activators, Wnt and Met, might provide an efficient strategy for breast cancer treatment.