J
Jürgen Schauber
Researcher at Ludwig Maximilian University of Munich
Publications - 87
Citations - 10349
Jürgen Schauber is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Cathelicidin & Antimicrobial peptides. The author has an hindex of 40, co-authored 87 publications receiving 9355 citations. Previous affiliations of Jürgen Schauber include Veterans Health Administration & University of Würzburg.
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Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Journal ArticleDOI
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D–dependent mechanism
Jürgen Schauber,Robert A. Dorschner,Robert A. Dorschner,Alvin B. Coda,Alvin B. Coda,Amanda S. Büchau,Amanda S. Büchau,Philip T. Liu,David Kiken,David Kiken,Yolanda R. Helfrich,Sewon Kang,Hashem Z Elalieh,Andreas Steinmeyer,Ulrich Zügel,Daniel D. Bikle,Robert L. Modlin,Richard L. Gallo,Richard L. Gallo +18 more
TL;DR: What is believed to be a previously unexpected role for vitamin D3 in innate immunity is demonstrated, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection.
Journal ArticleDOI
Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin
Kenshi Yamasaki,Jürgen Schauber,Alvin B. Coda,Henry Lin,Robert A. Dorschner,Norman M. Schechter,Chrystelle Bonnart,Pascal Descargues,Alain Hovnanian,Richard L. Gallo +9 more
TL;DR: Observations demonstrate that the balance of proteolytic activity at an epithelial interface will control innate immune defense and regulate the antimicrobial effects of cathelicidins in skin.
Journal ArticleDOI
Antimicrobial peptides and the skin immune defense system
Jürgen Schauber,Richard L. Gallo +1 more
TL;DR: Therapies targeting control of cathelicidin and other AMPs might provide new approaches in the management of infectious and inflammatory skin diseases.
Journal ArticleDOI
Butyrate Inhibits NF-κB Activation in Lamina Propria Macrophages of Patients with Ulcerative Colitis
H Lührs,T. Gerke,J. G. Müller,Ralph Melcher,Jürgen Schauber,F Boxberger,Wolfgang Scheppach,T Menzel +7 more
TL;DR: The decrease in DAI and mucosal inflammation in butyrate-treated patients is associated with a reduction of NF- s B translocation in lamina propria macrophages, correlated with a significant decrease in the Disease Activity Index.