Reiner Kiefersauer

TL;DR: The 2.6 Å crystal structure of the decanoyl-Arg-Val-Lys- Arg-chloromethylketone (dec-RVKR-cmk)–inhibited mouse furin ectodomain, the first PC structure, reveals an eight-stranded jelly-roll P domain associated with the catalytic domain, which will aid in the rational design of antiviral and antibacterial drugs.

TL;DR: The dinuclear [CuSMo(O)OH] cluster of CO dehydrogenase establishes a previously uncharacterized class of dinuclear molybdoenzymes containing the pterin cofactor.

TL;DR: The crystal structure reveals a 2-2-2 symmetric tetrameric assembly which depends on the natively glycosylated β-propeller blade IV and indicates that tetramerization of DP IV is a key mechanism to regulate its interaction with other components.

TL;DR: This modelled transmembrane complex provides a structural explanation for the uncoupling of haem biosynthesis observed in variegate porphyria patients and in plants after inhibiting PPO.

TL;DR: In this paper, a micropipette-based mounting of protein crystals with a controlled stream of air allows an accurate adjustment of the humidity at the crystal, and demonstrates the use of this method in combination with shock-freezing to improve crystal order.