R
Rolf Eckert
Researcher at Humboldt State University
Publications - 5
Citations - 1323
Rolf Eckert is an academic researcher from Humboldt State University. The author has contributed to research in topics: Tumor necrosis factor alpha & Messenger RNA. The author has an hindex of 4, co-authored 5 publications receiving 1287 citations. Previous affiliations of Rolf Eckert include Martin Luther University of Halle-Wittenberg.
Papers
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Journal ArticleDOI
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.
Alexey Kotlyarov,Armin Neininger,Carola Schubert,Rolf Eckert,Carmen Birchmeier,Hans-Dieter Volk,Matthias Gaestel +6 more
TL;DR: It is concluded that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-α at a post-transcriptional level.
Journal ArticleDOI
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels.
Armin Neininger,Dimitris L. Kontoyiannis,Alexey Kotlyarov,Reinhard Winzen,Rolf Eckert,Hans-Dieter Volk,Helmut Holtmann,George Kollias,Matthias Gaestel +8 more
TL;DR: The data provide in vivo evidence that the AU-rich 3′-UTRs of TNF and IL-6 are downstream to MK2 signaling and make MK2 an essential component of mechanisms that regulate biosynthesis of IL- 6 at the levels of mRNA stability, and of T NF mainly through TNF-ARE-dependent translational control.
Kotlyarov, A. et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat. Cell Biol. 1, 94-97
Alexey Kotlyarov,Armin Neininger,Carola Schubert,Rolf Eckert,Carmen Birchmeier,H. D. and Volk,Matthias Gaestel +6 more
Journal ArticleDOI
Splenopentin (DAc-SP-5) accelerates the restoration of myelopoietic and immune systems after sublethal radiation in mice
H. Weber,Jaroslaw Maciejewski,Rolf Eckert,Manfred Dr. Rer.Nat. Schutt,Wolfgang Diezel,Hans-Dieter Volk +5 more
TL;DR: DAc-SP-5 treated mice showed in the first weeks postexposure a significantly higher number of bone marrow derived cells as well as granulocyte-macrophage and macrophage colony-forming cells and may be a useful substance for treating secondary forms ofBone marrow depression.
Patent
Acylated splenopentins, methods for their synthesis and their use
Klaus Dr.Rer.Nat. Forner,Angelika Ehrlich,Diezel W,Rolf Eckert,Elke Dr. Rer.Nat. Euthin,Eberhard Krause,Peter Slonina,Hans-Dieter Volk,Heinrich Dr. Sc.Nat. Repke,Monika Georgi,Martina Leidert,Michael Bienert,Michail Ovcinnikov,Ralph Schmidt,Manfred Dr Rer Nat Schuett,Renate Dr. Rer.Nat. Mentel,Winfried Dr.Med. Breustedt +16 more
TL;DR: In this article, the authors proposed new compounds of acylated splenopentins of Formula I R.sup.4 I wherein R 1, R 2, R 3, R 4 are as defined in the specification, methods for their synthesis by acylation of splenopsentins, as well as their use as pharmacologically active peptides which are suitable for normalizing the function of the immunological system in primary and secondary immunological deficiencies.