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Renato Socodato
Researcher at Instituto de Biologia Molecular e Celular
Publications - 48
Citations - 1167
Renato Socodato is an academic researcher from Instituto de Biologia Molecular e Celular. The author has contributed to research in topics: Microglia & Glutamate receptor. The author has an hindex of 17, co-authored 46 publications receiving 850 citations. Previous affiliations of Renato Socodato include Institute of Business & Medical Careers & University of Coimbra.
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Journal ArticleDOI
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair.
Helena S. Domingues,Helena S. Domingues,Camila C. Portugal,Camila C. Portugal,Renato Socodato,Renato Socodato,João B. Relvas,João B. Relvas +7 more
TL;DR: Understanding the cellular and molecular mechanisms underlying glial cell communication and how they influence oligodendrocyte differentiation and myelination is fundamental to uncover novel therapeutic strategies for myelin repair.
Book ChapterDOI
Nitric oxide in the nervous system: biochemical, developmental, and neurobiological aspects.
Marcelo Cossenza,Renato Socodato,Camila C. Portugal,Ivan Domith,Luis F. H. Gladulich,Thaísa G. Encarnação,Karin da Costa Calaza,Henrique Rocha Mendonça,Paula Campello-Costa,Roberto Paes-de-Carvalho +9 more
TL;DR: A number of studies show that NO regulates neurotransmitter release and different aspects of synaptic dynamics, such as differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, and modulation of synaptic efficacy.
Journal ArticleDOI
Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype
Camila C. Portugal,Renato Socodato,Teresa Canedo,Cátia M. Silva,Tânia Martins,Vivian S. M. Coreixas,Vivian S. M. Coreixas,Erick Correia Loiola,Erick Correia Loiola,Burkhard Gess,Burkhard Gess,Dominik Röhr,Ana Raquel Santiago,Peter Young,Richard D. Minshall,Roberto Paes-de-Carvalho,António F. Ambrósio,João B. Relvas +17 more
TL;DR: This work demonstrated that ascorbate uptake through SVCT2 was critical for the homeostasis of microglia, the resident myeloid cells of the CNS that are essential for proper functioning of the nervous tissue and hints that dysregulation of asCorbate transport might play a role in neurological disorders.
Journal ArticleDOI
Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity
Joana F. Henriques,Camila C. Portugal,Teresa Canedo,Teresa Canedo,João B. Relvas,Teresa Summavielle,Renato Socodato +6 more
TL;DR: An overview of literature relating alcohol exposure with microglia activation and brain inflammation is presented, highlighting thatmicroglia are critical regulators of alcohol responses in the CNS and are critical for the development of better therapeutics for mitigating the neurotoxicity induced by alcohol.
Journal ArticleDOI
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration
Renato Socodato,Camila C. Portugal,Teresa Canedo,Artur Rodrigues,Tiago Almeida,Joana F. Henriques,Sandra H. Vaz,João P. Magalhães,Cátia M. Silva,Filipa I. Baptista,Renata L. Alves,Vanessa Coelho-Santos,Ana M. F. P. Silva,Roberto Paes-de-Carvalho,Ana Magalhães,Cord Brakebusch,Ana M. Sebastião,Teresa Summavielle,Teresa Summavielle,António F. Ambrósio,João B. Relvas,João B. Relvas +21 more
TL;DR: The results indicate that disturbing Rho GTPase signaling in microglia can directly cause neurodegeneration.