R
Rexford S. Ahima
Researcher at Johns Hopkins University
Publications - 268
Citations - 37768
Rexford S. Ahima is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Leptin & Insulin resistance. The author has an hindex of 80, co-authored 245 publications receiving 34783 citations. Previous affiliations of Rexford S. Ahima include Johns Hopkins University School of Medicine & Harvard University.
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Changes in Fasting and Prandial Gut and Adiposity Hormones Following Vertical Sleeve Gastrectomy or Roux-en-Y-Gastric Bypass: an 18-Month Prospective Study
Naji Alamuddin,Marion L. Vetter,Rexford S. Ahima,Louise Hesson,Scott Ritter,Alyssa M. Minnick,Lucy F. Faulconbridge,Kelly C. Allison,David B. Sarwer,Jesse Chittams,Noel N. Williams,Matthew R. Hayes,James Loughead,Ruben C. Gur,Thomas A. Wadden +14 more
TL;DR: The data suggest a role of gastrointestinal hormones as mediators of weight loss in VSG and RYGB at 18 months, and an exaggerated post-prandial response in GLP-1 and PYY3–36 at 6 months.
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Insulin Secretion Is Increased in Pancreatic Islets of Neuropeptide Y-Deficient Mice
Yumi Imai,Hiral R. Patel,Evan J. Hawkins,Nicolai M. Doliba,Franz M. Matschinsky,Rexford S. Ahima +5 more
TL;DR: Results suggest that endogenous NPY tonically inhibits insulin secretion from islets and a reduction of islet NPY may serve as one of the mechanisms to increase insulin secretion when islets compensate for insulin resistance associated with obesity.
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Neuroendocrine and metabolic effects of adipocyte-derived hormones
TL;DR: Obesity is characterized by an increase in adipose tissue mass, and there is now growing evidence that adipocyte secretory factors regulate energy homoeostasis, as well as cardiovascular and immune systems.
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Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression.
Yumi Imai,Siobhan Boyle,Gladys M. Varela,Emilie Caron,Xiaoyan Yin,Raina Dhir,Ravindra Dhir,Mark J. Graham,Rexford S. Ahima +8 more
TL;DR: Microarray analysis and results indicate that Plin2 has diverse metabolic and structural roles in the liver, and its downregulation promotes hepatic fibrosis and proliferation.
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Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol
Rexford S. Ahima,Hiralben R. Patel,Nobuhiko Takahashi,Yong Qi,Stanley M. Hileman,Michael Zasloff +5 more
TL;DR: It is shown that a spermine metabolite of cholesterol (MSI-1436) decreases body weight by suppressing feeding and preventing the reduction in energy expenditure, hormonal changes, and patterns of neuropeptide expression normally associated with weight loss.