R
Rexford S. Ahima
Researcher at Johns Hopkins University
Publications - 268
Citations - 37768
Rexford S. Ahima is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Leptin & Insulin resistance. The author has an hindex of 80, co-authored 245 publications receiving 34783 citations. Previous affiliations of Rexford S. Ahima include Johns Hopkins University School of Medicine & Harvard University.
Papers
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Journal ArticleDOI
Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron
Jonathan Cedernaes,Wenyu Huang,Kathryn Moynihan Ramsey,Nathan Waldeck,Lei Cheng,Biliana Marcheva,Chiaki Omura,Yumiko Kobayashi,Clara Bien Peek,Daniel C. Levine,Ravindra Dhir,Raj Awatramani,Christopher A. Bradfield,Xiaozhong Wang,Joseph S. Takahashi,Mohamad Mokadem,Rexford S. Ahima,Joseph Bass +17 more
TL;DR: It is demonstrated that the clock transcription pathway maximizes eating during wakefulness and glucose production during sleep through autonomous circadian regulation of NPY/AgRP neurons, and that the AgRP clock mediates the transcriptional response to leptin.
Journal ArticleDOI
Loss of IL-15 receptor α alters the endurance, fatigability,and metabolic characteristics of mouse fast skeletal muscles
Emidio E. Pistilli,Sasha Bogdanovich,Sasha Bogdanovich,Fleur C. Garton,Nan Yang,Jason P. Gulbin,Jennifer D. Conner,Barbara G. Anderson,Le Bris S. Quinn,Kathryn N. North,Rexford S. Ahima,Tejvir S. Khurana +11 more
TL;DR: It is shown that loss of IL-15Rα induces a functional oxidative shift in fast muscles, substantially increasing fatigue resistance and exercise capacity and is consistent with a shift toward a slower, more oxidative phenotype.
Journal ArticleDOI
Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.
Joseph Kelly,Carol F. Elias,Charlotte E. Lee,Rexford S. Ahima,Randy J. Seeley,Christian Bjørbæk,Takakazu Oka,Clifford B. Saper,Jeffrey S. Flier,Joel K. Elmquist +9 more
TL;DR: The hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin is supported.
Book ChapterDOI
Adipokines that link obesity and diabetes to the hypothalamus.
TL;DR: There is emerging evidence that leptin, adiponectin, and resistin act through overlapping pathways, and understanding the signal transduction of adipocyte hormones will provide novel insights on the pathogenesis and treatment of obesity, diabetes, and various metabolic disorders.
Journal ArticleDOI
Lipid accumulation and oxidation in glioblastoma multiforme.
Bouchra Taïb,Amine Mohamed Aboussalah,Mohammed Moniruzzaman,Suming Chen,Norman J. Haughey,Sangwon F. Kim,Rexford S. Ahima +6 more
TL;DR: It is demonstrated that monounsaturated fatty acids promote GBM proliferation via triglyceride metabolism, suggesting a novel lipid droplet-mediated pathway which may be targeted for GBM treatment.