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Ricarda Niggeweg
Researcher at European Bioinformatics Institute
Publications - 4
Citations - 361
Ricarda Niggeweg is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Nuclear pore & Elongation factor. The author has an hindex of 4, co-authored 4 publications receiving 332 citations.
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Journal ArticleDOI
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.
Yury Belyi,Ricarda Niggeweg,Bastian Opitz,Martin Vogelsgesang,Stefan Hippenstiel,Matthias Wilm,Klaus Aktories +6 more
TL;DR: This work reports that L. pneumophila produces a glucosyltransferase, which selectively modifies an mammalian protein by using UDP-glucose as a cosubstrate, showing a mode of inhibition of protein synthesis by microbial pathogens.
Journal ArticleDOI
RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.
Daniel Forler,Gwénaël Rabut,Francesca D. Ciccarelli,Andrea Herold,Thomas Köcher,Ricarda Niggeweg,Peer Bork,Jan Ellenberg,Elisa Izaurralde +8 more
TL;DR: The results indicate that RanBP2 provides a major binding site for NXF1 at the cytoplasmic filaments of the NPC, thereby restricting its diffusion in the cy toplasm after NPC translocation, so that the nuclear levels of the protein decrease and export of bulk mRNA is impaired.
Journal ArticleDOI
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3′ UTR: translational repression for dosage compensation
Kent E. Duncan,Marica Grskovic,Claudia Strein,Karsten Beckmann,Ricarda Niggeweg,Irina Abaza,Fátima Gebauer,Matthias Wilm,Matthias W. Hentze +8 more
TL;DR: The results reveal a novel functional role for UNR as a translational repressor and indicate that UNR is a key component of a "fail-safe" dosage compensation regulatory system that prevents toxic MSL-2 synthesis in female cells.
Journal ArticleDOI
A general precursor ion-like scanning mode on quadrupole-TOF instruments compatible with chromatographic separation.
Ricarda Niggeweg,Thomas Köcher,Marc Gentzel,Alessia Buscaino,Mikko Taipale,Asifa Akhtar,Matthias Wilm +6 more
TL;DR: A fast, sensitive, multiplexed precursor ion scanning mode – implemented on a quadrupole‐TOF instrument – that allows the specific detection of any modified peptide or molecule that reveals itself by a specific fragment ion or pattern of fragment ions within a complex proteomic sample is presented.