R
Richa Gupta
Researcher at University of North Carolina at Chapel Hill
Publications - 17
Citations - 1627
Richa Gupta is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Microvesicles & Isoschizomer. The author has an hindex of 8, co-authored 17 publications receiving 1092 citations. Previous affiliations of Richa Gupta include Panjab University, Chandigarh & Drexel University.
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Journal ArticleDOI
Exosomes as drug delivery vehicles for Parkinson's disease therapy.
Matthew J. Haney,Natalia L. Klyachko,Yuling Zhao,Richa Gupta,Evgeniya G. Plotnikova,Zhijian He,Tejash Patel,Aleksandr Piroyan,Marina Sokolsky,Alexander V. Kabanov,Elena V. Batrakova +10 more
TL;DR: ExoCAT provided significant neuroprotective effects in in vitro and in vivo models of PD and has a potential to be a versatile strategy to treat inflammatory and neurodegenerative disorders.
Journal ArticleDOI
GDNF-Transfected Macrophages Produce Potent Neuroprotective Effects in Parkinson's Disease Mouse Model
Yuling Zhao,Matthew J. Haney,Richa Gupta,John Peyton Bohnsack,Zhijian He,Alexander V. Kabanov,Elena V. Batrakova +6 more
TL;DR: Genetically-modified macrophages are evaluated for active targeted brain delivery of glial cell-line derived neurotropic factor (GDNF) to provide neuroprotective effects and serve as a new technology based on cell-mediated active delivery of therapeutic proteins that attenuate and reverse progression of PD.
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Physical characterization and profiling of airway epithelial derived exosomes using light scattering.
Mehmet Kesimer,Richa Gupta +1 more
TL;DR: The results indicated that epithelial cells release vesicles with distinct physical properties and sizes, which may provide a unique tool for researchers to elucidate the unanswered questions in normal airway biology and innate and adaptive defense, including the remodeling of airways during inflammation, tumorigenesis and metastasis.
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Intercellular Communication between Airway Epithelial Cells Is Mediated by Exosome-Like Vesicles.
Richa Gupta,Giorgia Radicioni,Sabri Abdelwahab,Hong Dang,Jerome Carpenter,Michael Chua,Piotr A. Mieczkowski,John T. Sheridan,Scott H. Randell,Mehmet Kesimer +9 more
TL;DR: It is suggested that the transfer of exosomal cargo between airway epithelial cells significantly alters the qualitative and quantitative profiles of airway secretions, including mucin hypersecretion, and the miRNA cargo ofExosomes in target cells.
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Characterization of a glycoside hydrolase family 1 β-galactosidase from hot spring metagenome with transglycosylation activity.
TL;DR: A novel, thermostable, alkalophilic β-d-galactosidase was isolated from a metagenome of geothermal springs in northern Himalayan region of India and displayed high transglycosylation activity with wide acceptor specificity leading to the formation of prebiotic galacto-oligosaccharides whereas its lactose hydrolysis potential was low.