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Open AccessJournal ArticleDOI

Intercellular Communication between Airway Epithelial Cells Is Mediated by Exosome-Like Vesicles.

Richa Gupta, +9 more
- 01 Feb 2019 - 
- Vol. 60, Iss: 2, pp 209-220
TLDR
It is suggested that the transfer of exosomal cargo between airway epithelial cells significantly alters the qualitative and quantitative profiles of airway secretions, including mucin hypersecretion, and the miRNA cargo ofExosomes in target cells.
Abstract: 
Airway epithelium structure/function can be altered by local inflammatory/immune signals, and this process is called epithelial remodeling. The mechanism by which this innate response is regulated,...

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Citations
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Journal ArticleDOI

Epithelial cell dysfunction, a major driver of asthma development

Irene H. Heijink, +10 more
- 16 Jun 2020 - 
TL;DR: The role of airway epithelial barrier function in the susceptibility to develop asthma is focused on and novel insights in the modulation of epithelial cell dysfunction in asthma are proposed.
Journal ArticleDOI

The roles of exosomal miRNAs and lncRNAs in lung diseases.

Yang Li, +4 more
- 13 Nov 2019 - 
TL;DR: This review will summarize recent knowledge about the roles of exosomal miRNAs and lncRNAs in lung diseases, which has shed light on the discovery of novel diagnostic methods and treatments for these disorders.
Journal ArticleDOI

Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells is Essential to Maintain Lung Homeostasis.

Elyse Y. Bissonnette, +3 more
- 15 Oct 2020 - 
TL;DR: Characteristics and functions of AMs and lung ECs as well as different communication mechanisms these cells utilize to maintain lung immune balance and response to pathogens are revisited.
Journal ArticleDOI

Extracellular vesicles: novel communicators in lung diseases.

Aradhana Mohan, +4 more
- 08 Jul 2020 - 
TL;DR: This comprehensive review focuses on what is currently known about the role of EVs as markers and mediators of lung pathologies including COPD, pulmonary hypertension, asthma, lung cancer and ALI/ARDS and explores the role EVs can potentially serve as therapeutics for these lung diseases when released from healthy progenitor cells, such as mesenchymal stem cells.
Journal ArticleDOI

Cell-cell communication: old mystery and new opportunity.

Dongli Song, +5 more
- 27 Feb 2019 - 
References
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Journal ArticleDOI

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, +5 more
- 07 May 2007 - 
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

Davis J. McCarthy, +2 more
- 01 May 2012 - 
TL;DR: A flexible statistical framework is developed for the analysis of read counts from RNA-Seq gene expression studies, and parallel computational approaches are developed to make non-linear model fitting faster and more reliable, making the application of GLMs to genomic data more convenient and practical.
Journal ArticleDOI

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino, +55 more
- 19 Nov 2015 - 
TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
Journal ArticleDOI

Small-sample estimation of negative binomial dispersion, with applications to SAGE data

Mark D. Robinson, +1 more
- 29 Aug 2007 - 
TL;DR: A quantile-adjusted conditional maximum likelihood estimator for the dispersion parameter of the negative binomial distribution is derived and an "exact" test is derived that outperforms the standard approximate asymptotic tests.
Journal ArticleDOI

Muc5b is required for airway defence

Michelle G. Roy, +44 more
- 16 Jan 2014 - 
TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.
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