S
Scott H. Randell
Researcher at University of North Carolina at Chapel Hill
Publications - 207
Citations - 11919
Scott H. Randell is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cystic fibrosis & Respiratory epithelium. The author has an hindex of 59, co-authored 207 publications receiving 9766 citations. Previous affiliations of Scott H. Randell include Broad Institute.
Papers
More filters
Journal ArticleDOI
Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus.
Simon J. Anthony,Simon J. Anthony,Kirsten V. K. Gilardi,Vineet D. Menachery,Tracey Goldstein,B. Ssebide,Ruth Mbabazi,Isamara Navarrete-Macias,Eliza Liang,Eliza Liang,Heather L. Wells,Allison L. Hicks,Alexandra Petrosov,Denis K. Byarugaba,Kari Debbink,Kenneth H. Dinnon,Trevor Scobey,Scott H. Randell,Boyd Yount,Michael R. Cranfield,Michael R. Cranfield,Christine K. Johnson,Ralph S. Baric,Walter Ian Lipkin,Jonna A. K. Mazet +24 more
TL;DR: A Mers-like CoV identified from a Pipistrellus cf.
Journal ArticleDOI
Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells
Frank A. Suprynowicz,Geeta Upadhyay,Ewa Krawczyk,Sarah C. Kramer,Jess D. Hebert,Xuefeng Liu,Hang Yuan,Chaitra Cheluvaraju,Phillip W. Clapp,Richard C. Boucher,Christopher M. Kamonjoh,Scott H. Randell,Richard Schlegel +12 more
TL;DR: It is found that conditionally reprogrammed CRCs share characteristics of adult stem cells and exhibit up-regulated expression of α6 and β1 integrins and decreased Notch signaling and an increased level of nuclear β-catenin.
Journal ArticleDOI
Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.
Vonn Walter,Xiaoying Yin,Matthew D. Wilkerson,Christopher R. Cabanski,Christopher R. Cabanski,Ni Zhao,Ying Du,Mei Kim Ang,Michele C. Hayward,Ashley H. Salazar,Katherine A. Hoadley,Karen J. Fritchie,Charles G. Sailey,Mark C. Weissler,William W. Shockley,Adam M. Zanation,Trevor Hackman,Leigh B. Thorne,William D. Funkhouser,Kenneth L. Muldrew,Andrew F. Olshan,Scott H. Randell,Fred A. Wright,Carol G. Shores,D. Neil Hayes +24 more
TL;DR: Four molecular classes of HNSCC are confirmed consistent with signatures established for squamous carcinoma of the lung, including deregulation of the KEAP1/NFE2L2 oxidative stress pathway, differential utilization of the lineage markers SOX2 and TP63, and preference for the oncogenes PIK3CA and EGFR.
Journal ArticleDOI
Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types
Matthew D. Wilkerson,Xiaoying Yin,Katherine A. Hoadley,Yufeng Liu,Michele C. Hayward,Christopher R. Cabanski,Kenneth L. Muldrew,C. Ryan Miller,Scott H. Randell,Mark A. Socinski,Alden M. Parsons,William K. Funkhouser,Carrie B. Lee,Patrick J. Roberts,Leigh B. Thorne,Philip S. Bernard,Charles M. Perou,D. Neil Hayes +17 more
TL;DR: Lung SCC consists of four mRNA expression subtypes that have different survival outcomes, patient populations, and biological processes, and the subtypes stratify patients for more precise prognosis and targeted research.
Journal ArticleDOI
Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
Trevor Scobey,Boyd Yount,Amy C. Sims,Eric F. Donaldson,Sudhakar Agnihothram,Vineet D. Menachery,Rachel L. Graham,Jesica Swanstrom,Peter F. Bove,Jeeho D. Kim,Sonia Grego,Scott H. Randell,Ralph S. Baric +12 more
TL;DR: In this paper, the authors synthesize a panel of contiguous cDNAs that spanned the entire genome, and transfected full-length transcripts recovered several recombinant viruses (rMERS-CoV) that contained the expected marker mutations inserted into the component clones.