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Richard A.J. Janssen
Researcher at Galápagos NV
Publications - 38
Citations - 1740
Richard A.J. Janssen is an academic researcher from Galápagos NV. The author has contributed to research in topics: Lymphocyte & Fibroblast migration. The author has an hindex of 22, co-authored 37 publications receiving 1570 citations. Previous affiliations of Richard A.J. Janssen include Tufts Medical Center & Radboud University Nijmegen.
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Journal ArticleDOI
Calpain Regulates Actin Remodeling during Cell Spreading
David Potter,Jennifer S. Tirnauer,Richard A.J. Janssen,Dorothy E. Croall,Christina N. Hughes,Kerry A. Fiacco,James W. Mier,Masatoshi Maki,Ira M. Herman +8 more
TL;DR: Failure of the intimately related processes of filopodia formation and lamellar extension indicate that calpain is intimately involved in actin remodeling and cell spreading.
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Phase-II study of subcutaneous interleukin-2 in unselected patients with advanced renal-cell cancer on an outpatient basis
TL;DR: Subcutaneous IL-2 is clinically active, has an acceptable toxicity, and can be given to patients with concomitant disease, according to a single-institution phase II study.
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Zebrafish development and regeneration : new tools for biomedical research
Sebastiaan A. Brittijn,Suzanne J. Duivesteijn,Mounia Belmamoune,Laura F.M. Bertens,Wilbert Bitter,Joost D. Debruijn,Danielle L. Champagne,Edwin Cuppen,Gert Flik,Christina M. J. E. Vandenbroucke-Grauls,Richard A.J. Janssen,Ilse M.L. de Jong,Edo Ronald de Kloet,Alexander Kros,Annemarie H. Meijer,Juriaan R. Metz,Astrid M. van der Sar,Marcel J. M. Schaaf,Stefan Schulte-Merker,Herman P. Spaink,Paul P. Tak,Fons J. Verbeek,Margriet J. Vervoordeldonk,Freek J. Vonk,Frans Witte,Huipin Yuan,Michael K. Richardson +26 more
TL;DR: Preliminary data on assays for compounds that modulate skeletal patterning, bone turnover, immune responses, inflammation and early-life stress, and proof-of-concept studies on the localised targeting of compounds into regeneration blastemas using microcarriers are presented.
Journal ArticleDOI
Phase-I study of intravenously applied bispecific antibody in renal-cell cancer-patients receiving subcutaneous interleukin-2
BJ Kroesen,Jan Buter,Dt Sleijfer,Richard A.J. Janssen,W.T.A. van der Graaf,L. de Leij,Nh Mulder +6 more
TL;DR: It is concluded that i.v. BIS-1 F(ab')2 endows the T lymphocytes with a specific anti-EGP-2-directed cytotoxic potential.
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Development of a Gut-On-A-Chip Model for High Throughput Disease Modeling and Drug Discovery.
Claudia Beaurivage,Elena Naumovska,Yee Xiang Chang,Edo D. Elstak,Arnaud Nicolas,Heidi Wouters,Guido van Moolenbroek,Henriëtte L. Lanz,Sebastiaan Johannes Trietsch,Jos Joore,Paul Vulto,Richard A.J. Janssen,Kai S. Erdmann,Jan Stallen,Dorota Kurek +14 more
TL;DR: A robust high throughput 3D gut-on-a-chip model used for investigating hallmarks of inflammatory bowel disease and can be used for larger scale disease modeling, target validation and drug discovery purposes.