H
Henriëtte L. Lanz
Publications - 36
Citations - 1688
Henriëtte L. Lanz is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 24 publications receiving 1048 citations.
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Journal ArticleDOI
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Frans Schutgens,Frans Schutgens,Maarten B. Rookmaaker,Thanasis Margaritis,Anne C. Rios,Carola Ammerlaan,Carola Ammerlaan,Jitske Jansen,Linda Gijzen,Marianne K. Vormann,Annelotte M. Vonk,Marco C. Viveen,Fjodor A. Yousef Yengej,Fjodor A. Yousef Yengej,Sepide Derakhshan,Karin M. de Winter-de Groot,Benedetta Artegiani,Ruben van Boxtel,Edwin Cuppen,Antoni P. A. Hendrickx,Marry M. van den Heuvel-Eibrink,Ellen Heitzer,Henriëtte L. Lanz,Jeffrey M. Beekman,Jean-Luc Murk,Rosalinde Masereeuw,Frank C. P. Holstege,Jarno Drost,Marianne C. Verhaar,Hans Clevers +29 more
TL;DR: Conditions for the long-term growth of primary kidney tubular epithelial organoids, or ‘tubuloids’, are described and tubuloids grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.
Journal ArticleDOI
Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening
Martijn J. Wilmer,Chee Ping Ng,Henriëtte L. Lanz,Paul Vulto,Laura Suter-Dick,Rosalinde Masereeuw +5 more
TL;DR: The application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI are addressed.
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A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport.
Nienke R. Wevers,Dhanesh G. Kasi,Taylor Gray,Karlijn Wilschut,Benjamin Smith,Remko van Vught,Fumitaka Shimizu,Yasuteru Sano,Takashi Kanda,Graham Marsh,Sebastiaan Johannes Trietsch,Paul Vulto,Henriëtte L. Lanz,Birgit Obermeier +13 more
TL;DR: This in vitro model shows sufficient barrier function to study the passage of large molecules and is sensitive to differences in antibody penetration, which could support discovery and engineering of BBB-shuttle technologies.
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Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
Sebastiaan Johannes Trietsch,Elena Naumovska,Dorota Kurek,Meily C. Setyawati,Marianne K. Vormann,Karlijn Wilschut,Henriëtte L. Lanz,Arnaud Nicolas,Chee Ping Ng,Jos Joore,Stefan Kustermann,Adrian Roth,Thomas Hankemeier,Annie Moisan,Paul Vulto +14 more
TL;DR: A microfluidic device supporting the growth and function of extracellular matrix-supported intestinal tubules is developed, and the effect of staurosporine and acetylsalicylic acid on barrier integrity is evaluated.
Journal ArticleDOI
High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform
Nienke R. Wevers,Remko van Vught,Karlijn Wilschut,Arnaud Nicolas,Chiwan Chiang,Henriëtte L. Lanz,Sebastiaan Johannes Trietsch,Jos Joore,Paul Vulto +8 more
TL;DR: A method for culturing three-dimensional networks of spontaneously active neurons and supporting glial cells in a microfluidic platform for parallel evaluation of compound effects is demonstrated.