R
Richard Appleton
Researcher at Boston Children's Hospital
Publications - 183
Citations - 9024
Richard Appleton is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Epilepsy & Epilepsy syndromes. The author has an hindex of 46, co-authored 181 publications receiving 8189 citations.
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Journal ArticleDOI
The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
Anthony G Marson,Asya M Al-Kharusi,Muna Alwaidh,Richard Appleton,Gus A. Baker,David Chadwick,Celia Cramp,Oliver C Cockerell,PN Cooper,Julie Doughty,Barbara Eaton,Carrol Gamble,Peter Goulding,Stephen Howell,Adrian Hughes,Margaret Jackson,Ann Jacoby,Mark Kellett,G. R. Lawson,John Paul Leach,Paola Nicolaides,Richard C. Roberts,Phil Shackley,Jing Shen,David F. Smith,Philip E. M. Smith,Catrin Tudur Smith,Alessandra Vanoli,Paula R Williamson +28 more
TL;DR: Lamotrigine is clinically better than carbamazepine, the standard drug treatment, for time to treatment failure outcomes and is therefore a cost-effective alternative for patients diagnosed with partial onset seizures.
Journal ArticleDOI
The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial.
Anthony G Marson,Asya M Al-Kharusi,Muna Alwaidh,Richard Appleton,Gus A. Baker,David Chadwick,Celia Cramp,Oliver C Cockerell,PN Cooper,Julie Doughty,Barbara Eaton,Carrol Gamble,Peter Goulding,Stephen Howell,Adrian Hughes,Margaret Jackson,Ann Jacoby,Mark Kellett,G. R. Lawson,John Paul Leach,Paola Nicolaides,Richard C. Roberts,Phil Shackley,Jing Shen,David F. Smith,Philip E. M. Smith,Catrin Tudur Smith,Alessandr a Vanoli,Paula R Williamson +28 more
TL;DR: Valproate is better tolerated than topiramate and more efficacious than lamotrigine, and should remain the drug of first choice for many patients with generalised and unclassified epilepsies, and because of known potential adverse effects of valproate during pregnancy, the benefits for seizure control in women of childbearing years should be considered.
Journal ArticleDOI
Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial.
John McIntyre,Sue Robertson,Elizabeth Norris,Richard Appleton,William P Whitehouse,Barbara Phillips,Tim Martland,Kathleen Berry,Jacqueline Collier,Stephanie L. Smith,Imti Choonara +10 more
TL;DR: Buccal midazolam was more effective than rectal diazepam for children presenting to hospital with acute seizures and was not associated with an increased incidence of respiratory depression.
Journal ArticleDOI
Febrile seizures: an update
C Waruiru,Richard Appleton +1 more
TL;DR: This review focuses on the latest knowledge and understanding of febrile seizures and outlines the more important issues in the management of children who present with an apparent “febrile seizure”.
Journal ArticleDOI
The treatment of sleep disorders with melatonin
TL;DR: While the response was not always complete, the study clearly showed that melatonin has an important role in the treatment of certain types of chronic sleep disorders.