Richard B. Kim

TL;DR: Transport of the angiotensin converting enzyme inhibitor enalapril, a substrate of Oatp1, the sodium-independent organic anion transporting polypeptide 1 cloned from rat liver, was studied in rat hepatocytes isolated from all zones of the liver and from enriched periportal and perivenous hepatocytes prepared by collagenase perfusion and zone-selective destruction with digitonin.

TL;DR: Coexpression of the organic cation transporter, OCTN1, expressed in human cardiac myocytes, intensifies quinidine-induced HERG block, establishing a critical hypothesis that variable drug transporter activity may be a potential risk factor for torsade de pointes.

TL;DR: This study demonstrates the important roles of OATP1B transporters to the hepatic disposition and clearance of docetaxel, and supporting roles of these transporter for docetxel pharmacokinetics.

TL;DR: Renal allograft survival is lower in African American patients compared with white patients and pharmacodynamic responses to cyclosporine have not been compared among ethnic groups.

TL;DR: Performing S2P after age 3 months may optimize survival of low- and intermediate-risk infants, and it is inferred that early referral for cardiac transplantation may increase their chance of survival.