R
Richard B. Kim
Researcher at University of Western Ontario
Publications - 380
Citations - 33088
Richard B. Kim is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 89, co-authored 328 publications receiving 30436 citations. Previous affiliations of Richard B. Kim include London Health Sciences Centre & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
TL;DR: Investigation of the role of organic anion transporting polypeptide (OATP) transporters to the disposition of doxorubicin demonstrates important roles for OATP1A/1B in transporter-mediated uptake and disposition ofDoxorUBicin.
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α1A-Adrenergic receptor polymorphism and vascular response
Gbenga G. Sofowora,Gbenga G. Sofowora,Victor Dishy,Victor Dishy,Ruth Landau,Ruth Landau,Hong Guang Xie,Hong Guang Xie,Harish C. Prasad,Harish C. Prasad,Daniel W. Byrne,Daniel W. Byrne,Richard M. Smiley,Richard M. Smiley,Richard B. Kim,Richard B. Kim,Alastair J. J. Wood,Alastair J. J. Wood,C. Michael Stein,C. Michael Stein +19 more
TL;DR: This work examined the hypothesis that a common polymorphism of α1A‐adrenergic receptor (Arg347Cys) affects in vivo response to phenylephrine and found it plausible that this polymorphism has a role in in vivo adrenergic response.
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A Fibroblast Growth Factor 21–Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease
Sarah Woolsey,Melanie D. Beaton,Sara E. Mansell,Matilde Leon-Ponte,Janice Yu,Christopher L. Pin,Paul C. Adams,Richard B. Kim,Rommel G. Tirona +8 more
TL;DR: The role of the lipid- and glucose-modulating hormone fibroblast growth factor 21 (FGF21) in the molecular mechanism regulating CYP3A4 expression in nonalcoholic fatty liver disease is investigated and an FGF21-PXR signaling pathway may be involved in decreased hepatic CYP 3A4 metabolic activity in NAFLD.
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Organic cation transporter variation and response to smoking cessation therapies
Andrew W. Bergen,Harold S. Javitz,Ruth Krasnow,Martha Michel,Denise Nishita,David V. Conti,Christopher K. Edlund,Pui-Yan Kwok,Jennifer B. McClure,Richard B. Kim,Sharon M. Hall,Rachel F. Tyndale,Timothy B. Baker,Neal L. Benowitz,Gary E. Swan +14 more
TL;DR: The functional OCT2 Ser270Ala polymorphism is nominally statistically significantly associated with abstinence among European-ancestry treatment-seeking smokers after adjustments for pharmacotherapy, demographics, population genetics, and without adjustment for multiple testing of 7 SNPs.
Journal ArticleDOI
Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2.
Ling Jie Meng,Pijun Wang,Allan W. Wolkoff,Richard B. Kim,Rommel G. Tirona,Alan F. Hofmann,K. Sandy Pang +6 more
TL;DR: The results suggest that transport of SLCT into rat liver is mediated in part by Oatp1 and OatP2, high-affinity pathways, a lower‐affinity pathway of unknown origin, and a nonsaturable pathway that is compatible with a transport system of high Km and/or passive diffusion.